Outcome of MRSA carriers in neurological early rehabilitation
© Rollnik; licensee BioMed Central Ltd. 2014
Received: 3 September 2013
Accepted: 11 February 2014
Published: 21 February 2014
Colonization with MRSA is believed to have deteriorating effects on neurological rehabilitation patients because MRSA carriers need to be isolated.
Medical records of neurological early rehabilitation patients (most of them after stroke) admitted to a large rehabilitation facility in Northern Germany in 2010 have been carefully reviewed with respect to MRSA status, outcome variables (functional independence), morbidity, and length of stay (LOS).
74/569 (13.0%) patients were MRSA positive on admission. MRSA carriers had a significantly longer LOS in early neurological rehabilitation (63.7 (37.1) vs. 25.8 (24.5) days, p < 0.001), worse functional status on admission (Barthel index (BI) 13.6 (9.9) vs. 25.6 (24.1), p < 0.001), worse Glasgow Coma Scale (9.5 (3.2) vs. 12.0 (3.3), p < 0.001), more co-diagnoses (20.5 (5.1) vs. 13.3 (5.5), p < 0.001), and higher Patient Clinical Complexity Levels (PCCL). The outcome was significantly worse among MRSA positive patients (BI 25.5 (21.2) vs. 47.4 (31.0), p < 0.001; Early Rehabilitation Index −47.3 (51.4) vs. -26.0 (35.4), p < 0.001). Isolated patients had slightly less therapy per day (131.6 (16.6) vs. 140.2 (18.7) min/day, p < 0.001), but the overall sum of therapy was significantly larger in the MRSA positive group due to longer LOS.
Functional recovery of MRSA carriers in early neurological rehabilitation is worse than in MRSA negative patients. Poorer outcome is not resulting from isolation (less therapy) but from functional status and higher morbidity on admission.
Several studies suggest that colonization with methicillin resistant Staphylococcus aureus (MRSA) is a growing problem in rehabilitation and nursing facilities. In 1982, the rate of MRSA colonized patients in a U. S. rehabilitation center was only 0.44% . Eight years later, 20.6% of veterans in a nursing home were found to be MRSA positive (nasal colonization) . A decade ago, geriatric rehabilitation clinics have reported colonization rates ranging from 4.8%  to 9.8% . It has also been shown that MRSA positive have a significantly longer length of stay (LOS) than MRSA negative rehabilitants [4, 5]. Strict isolation of these patients is still recommended [6–8] but raises ethical concerns . Isolation may cause psychological distress like depression and anxiety .
Risk factors for MRSA colonization are: former colonization with MRSA, hospitalization in the past, mechanical ventilation, antibiotic therapy, co-morbidity, tracheostomy, renal failure, and chronic skin infections [11–13]. It is evident that neurological early rehabilitation patients carry many of these risk factors, in particular hospitalization including long lasting intensive care therapy, mechanical ventilation, tracheostomy, antibiotic therapy (due to aspiration pneumonia), and co-morbidity [14, 15]. However, only little data is available on MRSA incidence and prevalence in neurological early rehabilitation. In the BDH Clinic Hessisch Oldendorf, we have found 6.6% MRSA positive patients on intensive and intermediate care wards , and a recent multicenter study revealed a rate of 14.5% among ten large neurological early rehabilitation facilities in Germany .
It is hyothesized that strict isolation due to MRSA colonization limits rehabilitation, but there are no studies focusing on the outcome of MRSA colonized neurological rehabilitation patients, yet.
The BDH Clinic Hessisch Oldendorf is a neurological hospital (including stroke unit and intensive care units) and rehabilitation facility in Northern Germany with more than 100 neurological early rehabilitation beds. With respect to MRSA the clinic is practicing a strict “search and destroy” strategy. All patients are systematically screened on admission (nose and orophharynx) using a polymerase chain reaction (PCR). If positive, a traditional culture is done to confirm MRSA colonization. All MRSA carriers are strictly isolated and nasal decolonization with mupirocin is initiated. Isolation will be continued until three subsequent samples are negative (first sample three days after last administration of mupirocin).
To find out whether MRSA colonization has any impact on outcome parameters, medical records of n = 569 neurological early rehabilitation patients admitted to the BDH Clinic Hessisch Oldendorf in 2010 have been reviewed. Barthel index (BI) , Early Rehabilitation Barthel Index (ERBI) , Glasgow Coma Scale (GCS) , Coma Remission Scale (CRS) , and Early Functional Abilities (EFA)  on admission have been included in the analysis. As major outcome parameters, BI and ERBI have been recorded. In addition, length of stay (LOS), morbidity (number of co-diagnoses and Patient Clinical Complexity Level – PCCL ), and duration of physiotherapy, ergotherapy, speech therapy, and cognitive therapy have been analyzed.
Statistical analyses included t-tests for independent samples, univariate analyses of variance, and bivariate Pearson correlations. Differences were regarded as significant with p < 0.05.
Local ethics committee (BDH-Clinic Hessisch Oldendorf) had no objections because the study was a retrospective database analysis, only (no intervention).
Main diagnoses of MRSA positive and negative neurological early rehabilitation patients
Other main diagnosis
Characteristics of MRSA positive and negative neurological early rehabilitation patients
Length of stay (LOS) – referring hospital [days]
LOS – neurological early rehabilitation [days]
LOS – entire neurological rehabilitation [days]
Number of co-diagnoses [n]
Barthel Index (BI) on admission [0 to 100]
Barthel index on discharge [0 to 100]
Early Rehabilitation Index (ERI) on admission [−325 to 0]
ERI on discharge [−325 to 0]
Coma Remission Scale (CRS) [0 to 24]
Glasgow Coma Scale (GCS) [3 to 15]
Early functional abilities (EFA) – vegetative [4 to 20]
EFA – faciooral [4 to 20]
EFA – sensorymotor [7 to 35]
EFA – cognitive [5 to 25]
Speech therapy [min/day]
Cognitive therapy [min/day]
Total main therapies [min/day]
PCCL (Patient Clinical Complexity Level) of MRSA positive and negative patients
MRSA positive neurological early rehabilitation patients had significantly more physiotherapy and less speech and cognitive therapy per day (Table 2). Ergotherapy did not differ between the groups. Altogether, MRSA carriers had about 11 min less therapy per day than negative patients (Table 2). Because of significantly longer LOS of MRSA positive patients, the overall sum of therapeutic procedures during early rehabilitation was considerably higher in this group.
A univariate analysis of variance was performed using the following model: changes in BI (discharge minus admission) as dependent variable; colonization with MRSA and PCCL as categorical independent variables; age, BI on admission, GCS on admission, CRS on admission, duration of isolation, physiotherapy, ergotherapy, speech therapy, and cognitive therapy per day as independent covariates. This model explained 69.1% of the data variation (p < 0.001). PCCL had a highly significant influence (p < 0.001), but not MRSA colonization itself. Age (p < 0.05), physiotherapy per day (p < 0.01), and cognitive therapy per day (p < 0.05) also had a significant influence on changes in BI. CRS, GCS, ergotherapy, and speech therapy did not.
MRSA colonization is a growing problem in neurological rehabilitation. Recent studies suggest that the prevalence of MRSA carriers among early rehabilitation patients ranges from 6.6% to 14.5% [16, 17]. Colonization with MRSA may limit neurological early rehabilitation because patients need to be isolated. MRSA carriers must not participate in group therapies which may lead to intensive human-resource allocation and less therapy for this cohort of rehabilitants. There are, however, no studies available focusing on the impact of MRSA colonization on the outcome of early rehabilitation patients, yet.
In the present study, there was a rate of 13.0% MRSA carriers on admission to the early rehabilitation facility which is in line with previously published results . Patients had to be isolated for nearly half of their stay in neurological early rehabilitation (31.5 days isolation vs. 63.7 days LOS early rehabilitation). This finding suggests that decolonization procedures (local treatment with mupirocin ) are successful.
It is well known that age has an impact on the outcome of neurological patients, e.g. after stroke . The present study also demonstrated a negative correlation between age and improvement in activities of daily living (BI) suggesting that age is a risk factor for poor neurological outcome. However, MRSA positive and negative groups did not differ with respect to age.
In line with previous studies, MRSA positive patients had a higher morbidity (PCCL, number of co-diagnoses), but LOS in the referring (primary) hospital was not different between both groups. Functional status (Barthel index, ERBI, CRS, EFA, GCS) was worse in the MRSA group on admission. LOS was significantly longer among MRSA carriers confirming previous findings [4, 5].
Surprisingly, overall sum therapy was significantly larger in the MRSA group which can be explained by longer LOS in this cohort. Intensity of therapy (min per day), however, was slightly smaller among MRSA carriers (131.6 vs. 140.2 min/day). While there was even more physiotherapy per day in the MRSA colonized group, speech and cognitive therapy were done less frequently. Ergotherapy did not differ. This finding suggests that MRSA colonized patients do not necessarily receive less therapy than MRSA negative rehabilitants. Even so, the outcome of MRSA carriers was worse. How can this finding be explained? It is well known that low functional status on admission and co-morbidity are risk factors for poor outcome [14, 24]. It emerges from literature that BI in the early phase is a strong predictor for long-term functional outcome . Poor outcome among MRSA carriers may be explained by worse functional status on admission. In addition, lower BI and ERBI values on admission account for longer LOS among MRSA carriers [14, 25]. This hypothesis is confirmed by a univariate analysis of variance: It turned out that BI improvement was strongly influenced by PCCL (as a measure of morbidity), age, and BI on admission. MRSA colonization itself had no independent influence on BI changes. Further studies on this topic are encouraged.
Outcome of MRSA colonized neurological early rehabilitation patients is worse than functional independence of MRSA free patients. This finding cannot be explained by isolation effects, e.g. less therapy, but by significantly worse functional status and morbidity of MRSA carriers on admission.
The author thanks, Ms. Pauline Scholz, study nurse, for her work on the database and reviewing the medical records.
- Aeilts GD, Sapico FL, Canawath HN, Malik GM, Montgomerie JZ: Methicillin-resistant Staphylococcus aureus colonization and infection in a rehabilitation facility. J Clin Microbiol. 1982, 16: 218-223.PubMedPubMed CentralGoogle Scholar
- Cederna JE, Terpenning MS, Ensberg M, Bardley SF, Kauffman CA: Staphylococcus aureus nasal colonization in a nursing home: eradication with mupirocin. Infect Control Hosp Epidemiol. 1990, 11: 13-16. 10.2307/30144250.View ArticlePubMedGoogle Scholar
- Heudorf U, Bremer V, Heuck D: MRSA-Besiedelung bei Bewohnern von Alten- und Pflegeheimen sowie bei Patienten einer geriatrischen Rehabilitationsklinik in Frankfurt am Main 1999. Gesundheitswesen. 2001, 63: 447-454. 10.1055/s-2001-15924.View ArticlePubMedGoogle Scholar
- Morrison L, Stolarek I: Does MRSA affect patient outcomes in the elderly? A retrospective pilot study. J Hosp Infect. 2000, 45: 169-171. 10.1053/jhin.2000.0727.View ArticlePubMedGoogle Scholar
- Hassouna H, Haq EU, Gall A: MRSA colonisation in spinal cord injury: implications on patients rehabilitation. Acta Orthop Belg. 2008, 74: 528-530.PubMedGoogle Scholar
- Minary-Dohen P, Bailly P, Bertrand X, Talon D: Methicillin-resistant Staphylococcus aureus (MRSA) in rehabilitation and chronic-care-facilities: what is the best strategy?. BMC Geriatr. 2003, 3: 5-10.1186/1471-2318-3-5.View ArticlePubMedPubMed CentralGoogle Scholar
- Webber KL, Macpherson S, Meagher A, Hutchinson S, Lewis B: The impact of strict isolation on MRSA positive patients: an action-based study undertaken in a rehabilitation center. Rehabil Nurs. 2012, 37: 43-50. 10.1002/RNJ.00007.View ArticlePubMedGoogle Scholar
- Kommission für Krankenhaushygiene und Infektionsprävention am RKI. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz. 1999, 42: 954-958. 10.1007/s001030050227.
- Pike JH, McLean D: Ethical concerns in isolating patients with methicillin-resistant Staphylococcus aureus on the rehabilitation ward: a case report. Arch Phys Med Rehabil. 2002, 83: 1028-1030. 10.1053/apmr.2002.33108.View ArticlePubMedGoogle Scholar
- Tarzi S, Kennedy P, Stone S, Evans M: Methicillin-resistant Staphylococcus aureus: psychological impact of hospitalization and isolation in an older adult population. J Hosp Infect. 2001, 49: 250-254. 10.1053/jhin.2001.1098.View ArticlePubMedGoogle Scholar
- Vovko P, Retelj M, Cretnik TZ, Jutersek B, Harlander T, Kolman J, Gubina M: Risk factors for colonization with MRSA in a long-term care facility in Slovenia. Infect Control Hosp Epidemiol. 2005, 26: 191-195. 10.1086/502525.View ArticlePubMedGoogle Scholar
- Aizen E, Ljubuncic Z, Ljubuncic P, Aizen I, Potasman I: Risk factors for MRSA colonization in a geriatric rehabilitation hospital. J Gerontol A Biol Sci Med Sci. 2007, 62: 1152-1156. 10.1093/gerona/62.10.1152.View ArticlePubMedGoogle Scholar
- Torres K, Sampathkumar P: Predictors of methicillin-resistant Staphylococcus aureus colonization at hospital admission. Am J Infect Control. 2013, 41: 1043-1047. 10.1016/j.ajic.2013.02.013.View ArticlePubMedGoogle Scholar
- Rollnik JD, Janosch U: Current trends in the length of stay in neurological early rehabilitation. Dtsch Arztebl Int. 2010, 107: 286-292.PubMedPubMed CentralGoogle Scholar
- Oehmichen F, Ketter G, Mertl-Rötzer M, Platz T, Puschendorf W, Rollnik JD, Schaupp M, Pohl M: Weaning from prolonged mechanical ventilation in neurological weaning units: an evaluation of the German Working Group for early Neurorehabilitation. Nervenarzt. 2012, 83: 1300-1307. 10.1007/s00115-012-3600-z.View ArticlePubMedGoogle Scholar
- Rollnik JD: Challenges for neurological rehabilitation in Germany. Akt Neurol. 2009, 36: 368-371. 10.1055/s-0029-1220390.View ArticleGoogle Scholar
- Thomas R: MRSA in early rehabilitation – incidence, prevalence and morbidity. Neurol Rehabil. 2013, 19: 118-122.Google Scholar
- Mahoney FI, Barthel DW: Functional evaluation: the Barthel index. Md State Med J. 1965, 14: 61-65.PubMedGoogle Scholar
- Rollnik JD: The Early Rehabilitation Barthel Index (ERBI). Rehabilitation (Stuttg). 2011, 50: 408-411. 10.1055/s-0031-1273728.View ArticleGoogle Scholar
- Teasdale G, Jennett B: Assessment of coma and impaired consciousness, a practical scale. Lancet. 1974, 2: 81-83.View ArticlePubMedGoogle Scholar
- Ortega-Suhrkamp E, von Wild KR: Standards of neurologic-neurosurgical early rehabilitation–a concept of the study group neurological-neurosurgical early rehabilitation. Acta Neurochir Supp. 2002, 79: 11-19.Google Scholar
- Alvsåker K, Walther SM, Kleffelgård I, Mongs M, Drægebø RA, Keller A: Inter-rater reliability of the early functional abilities scale. J Rehabil Med. 2011, 43: 892-899.View ArticlePubMedGoogle Scholar
- Kwakkel G, Kollen BJ: Predicting activities after stroke: what is clinically relevant?. Int J Stroke. 2013, 8: 25-32. 10.1111/j.1747-4949.2012.00967.x.View ArticlePubMedGoogle Scholar
- Pettersen R, Dahl T, Wyller TB: Prediction of long-term functional outcome after stroke rehabilitation. Clin Rehabil. 2002, 16: 149-159. 10.1191/0269215502cr482oa.View ArticlePubMedGoogle Scholar
- Rollnik J: Barthel-index as a length of stay predictor in neurological rehabilitation. Rehabilitation (Stuttg). 2009, 48: 91-94. 10.1055/s-0029-1202294.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/14/34/prepub
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