The time course of miR-223 expression and the correlation analysis between miR-223 and clinical information. A. miR-223 was highly expressed in 1 day and 3 days stroke patients. Box plots exhibited the time course of miR-223 expression in stroke patients. *, p < 0.05, 1 day vs. control; **, p < 0.01, 3 days vs. control. n = 75 in control group, n = 15 in 1 day group, n = 22 in 2 days group, n = 42 in 3 days group. B. miR-223 was significantly up-regulated in patients with LA and SA strokes. Box plots exhibited the miR-223 expression level among different subtypes. *, p < 0.05, LA vs. control; **, p < 0.01, SA vs. control. n = 75 in control, n = 37 in LA, n = 5 in CE, n = 9 in SA, n = 28 in UN. Data are median (25% percentile, 75% percentile). The Y axis showed the miR-223 expression levels by log2 change. C. The scatterplot showed miR-223 levels were negatively associated with NIHSS scores. r = −0.531, p < 0.01. D. The scatterplot showed miR-223 levels have a negative correlation with infarct volume of stroke patients. r = −0.265, p = 0.039.