Dementias

Section edited by Marwan Sabbagh

This section focuses on neurodegeneration. Topics of interest include, but are not limited to, Alzheimer’s disease, Parkinson’s Disease, frontotemporal dementias, Lewy body dementia, vascular dementia, mild cognitive impairment and basic aspects of neurodegenerative diseases and prion diseases.

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  1. Case report

    An unusual delusion of duplication in a patient affected by Dementia with Lewy bodies

    Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the...

    Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta and Francesco Marrosu

    BMC Neurology 2017 17:78

    Published on: 19 April 2017

  2. Study protocol

    Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development

    Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade p...

    Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G. Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M. Jorge Cardoso, Ana Carvalho, Jessica Collins…

    BMC Neurology 2017 17:75

    Published on: 18 April 2017

  3. Commentary

    Big data and data repurposing - using existing data to answer new questions in vascular dementia research

    Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost eff...

    Fergus N. Doubal, Myzoon Ali, G. David Batty, Andreas Charidimou, Maria Eriksdotter, Martin Hofmann-Apitius, Yun-Hee Kim, Deborah A. Levine, Gillian Mead, Hermann A. M. Mucke, Craig W. Ritchie, Charlotte J. Roberts, Tom C. Russ, Robert Stewart, William Whiteley and Terence J. Quinn

    BMC Neurology 2017 17:72

    Published on: 17 April 2017

  4. Research article

    Bapineuzumab for mild to moderate Alzheimer’s disease: a meta-analysis of randomized controlled trials

    Alzheimer’s disease (AD) is a globally prevalent neurodegenerative condition, clinically characterized by progressive memory loss and gradual impairment of cognitive functions. Bapineuzumab is a fully humanize...

    Abdelrahman Ibrahim Abushouk, Ahmed Elmaraezy, Amro Aglan, Reham Salama, Samar Fouda, Rana Fouda and Ammar M. AlSafadi

    BMC Neurology 2017 17:66

    Published on: 4 April 2017

  5. Research article

    Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study

    Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definiti...

    Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda…

    BMC Neurology 2016 16:253

    Published on: 8 December 2016

  6. Database

    A profile of The Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): two complementary longitudinal, clinical cohorts in the Netherlands

    Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mecha...

    Weiqi Liao, Renske E. G. Hamel, Marcel G. M. Olde Rikkert, Saskia M. Oosterveld, Pauline Aalten, Frans R. J. Verhey, Philip Scheltens, Nicole Sistermans, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Inez H. G. B. Ramakers and René J. F. Melis

    BMC Neurology 2016 16:242

    Published on: 25 November 2016

  7. Case report

    Sporadic Creutzfeldt-Jakob disease with unusual initial presentation as posterior reversible encephalopathy syndrome: a case report

    Creutzfeldt - Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative prion disease. MRI findings are included in diagnostic criteria for probable CJD, giving a sensitivity and specificity mor...

    Edgaras Dirzius, Renata Balnyte, Vesta Steibliene, Rymante Gleizniene, Inga Gudinaviciene, Andrius Radziunas and Kestutis Petrikonis

    BMC Neurology 2016 16:234

    Published on: 22 November 2016

  8. Research article

    Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study

    The smell sense reduction was considered to represent the potentially warning of early stage of neurodegenerative disorders. The Shanghai Aging Study provided us a unique opportunity to explore the association...

    Xiaoniu Liang, Ding Ding, Qianhua Zhao, Qihao Guo, Jianfeng Luo and Zhen Hong

    BMC Neurology 2016 16:199

    Published on: 20 October 2016

  9. Research article

    Anxiety and depression symptoms among caregivers of care-recipients with subjective cognitive decline and cognitive impairment

    Caregivers of care-recipients with mild cognitive impairment (MCI) or dementia experience high caregiver burden; however, the psychiatric burden of caregivers of care-recipients with subjective cognitive decli...

    Xiaoniu Liang, Qihao Guo, Jianfeng Luo, Fang Li, Ding Ding, Qianhua Zhao and Zhen Hong

    BMC Neurology 2016 16:191

    Published on: 3 October 2016

  10. Research article

    Risk factors for recurrent injurious falls that require hospitalization for older adults with dementia: a population based study

    Older adults with dementia are at an increased risk of falls, however, little is known about risk factors for recurrent injurious falls (a subsequent fall after the first fall has occurred) among this group. T...

    Lynn B. Meuleners, Michelle L. Fraser, Max K. Bulsara, Kyle Chow and Jonathon Q. Ng

    BMC Neurology 2016 16:188

    Published on: 29 September 2016

  11. Research article

    Decreased IL-8 levels in CSF and serum of AD patients and negative correlation of MMSE and IL-1β

    It is widely accepted that neuroinflammatory processes play an important role in the pathogenesis of Alzheimer’s disease (AD) and high levels of cytokines and chemokines are detected around Aβ plaques.

    Raphael Hesse, Anke Wahler, Pauline Gummert, Stefanie Kirschmer, Markus Otto, Hayrettin Tumani, Jan Lewerenz, Cathrin Schnack and Christine A. F. von Arnim

    BMC Neurology 2016 16:185

    Published on: 26 September 2016

  12. Research article

    Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer’s disease, mild cognitive impairment, or healthy controls: a two year follow-up study

    α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ha...

    Guro Berge, Sigrid B. Sando, Grethe Albrektsen, Camilla Lauridsen, Ina Møller, Gøril R. Grøntvedt, Geir Bråthen and Linda R. White

    BMC Neurology 2016 16:180

    Published on: 21 September 2016

  13. Case report

    Bilateral strio-pallido-dentate calcinosis (Fahr’s disease): report of seven cases and revision of literature

    Fahr’s disease is rare a neurodegenerative idiopathic condition characterized by symmetric and bilateral calcifications of basal ganglia, usually associated with progressive neuropsychiatric dysfunctions and m...

    Elisabetta Savino, Cecilia Soavi, Eleonora Capatti, Massimo Borrelli, Giovanni B. Vigna, Angelina Passaro and Giovanni Zuliani

    BMC Neurology 2016 16:165

    Published on: 8 September 2016

  14. Erratum

    Erratum to: PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury

    Flora M. Hammond, David N. Alexander, Andrew J. Cutler, Stephen D’Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella and Joao Siffert

    BMC Neurology 2016 16:160

    Published on: 2 September 2016

    The original article was published in BMC Neurology 2016 16:89

  15. Research article

    Cholinesterase inhibitors do not alter the length of stay in nursing homes among patients with Alzheimer’s disease: a prospective, observational study of factors affecting survival time from admission to death

    The survival time in nursing homes (NHs) in Alzheimer’s disease (AD) might be affected by sociodemographic/clinical characteristics, rate of disease progression, and use of specific medications and community-b...

    Carina Wattmo, Elisabet Londos and Lennart Minthon

    BMC Neurology 2016 16:156

    Published on: 31 August 2016

  16. Case report

    Applied multimodal diagnostics in a case of presenile dementia

    Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. The possibility of disease-modifying strategies has evoked a need for early and accurate diagnosis. To improve the accuracy of the ...

    Sonja Schönecker, Matthias Brendel, Marion Huber, Christian Vollmar, Hans-Juergen Huppertz, Stefan Teipel, Nobuyuki Okamura, Johannes Levin, Axel Rominger and Adrian Danek

    BMC Neurology 2016 16:131

    Published on: 9 August 2016

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