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  1. Research article

    To be active through indoor-climbing: an exploratory feasibility study in a group of children with cerebral palsy and typically developing children

    Cerebral Palsy (CP) is the most common cause of motor disabilities in children and young adults and it is also often associated with cognitive and physiological challenges. Climbing requires a multifaceted rep...

    Mark Schram Christensen, Thor Jensen, Camilla B. Voigt, Jens Bo Nielsen and Jakob Lorentzen

    BMC Neurology 2017 17:112

    Published on: 15 June 2017

  2. Research article

    Isolated transient vertigo: posterior circulation ischemia or benign origin?

    Isolated transient vertigo can be the only symptom of posterior circulation ischemia. Thus, it is important to differentiate isolated vertigo of a cerebrovascular origin from that of more benign origins, as pa...

    Tobias F. Blasberg, Lea Wolf, Christian Henke and Matthias W. Lorenz

    BMC Neurology 2017 17:111

    Published on: 14 June 2017

  3. Research article

    Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts

    HIV-infected persons with detectable cryptococcal antigen (CrAg) in blood have increased morbidity and mortality compared with HIV-infected persons who are CrAg-negative. This study examined neurocognitive fun...

    Martha P. Montgomery, Noeline Nakasujja, Bozena M. Morawski, Radha Rajasingham, Joshua Rhein, Elizabeth Nalintya, Darlisha A. Williams, Kathy Huppler Hullsiek, Agnes Kiragga, Melissa A. Rolfes, Renee Donahue Carlson, Nathan C. Bahr, Kate E. Birkenkamp, Yukari C. Manabe, Paul R. Bohjanen, Jonathan E. Kaplan…

    BMC Neurology 2017 17:110

    Published on: 12 June 2017

  4. Study protocol

    Video Game Rehabilitation for Outpatient Stroke (VIGoROUS): protocol for a multi-center comparative effectiveness trial of in-home gamified constraint-induced movement therapy for rehabilitation of chronic upper extremity hemiparesis

    Constraint-Induced Movement therapy (CI therapy) is shown to reduce disability, increase use of the more affected arm/hand, and promote brain plasticity for individuals with upper extremity hemiparesis post-st...

    Lynne V. Gauthier, Chelsea Kane, Alexandra Borstad, Nancy Strahl, Gitendra Uswatte, Edward Taub, David Morris, Alli Hall, Melissa Arakelian and Victor Mark

    BMC Neurology 2017 17:109

    Published on: 8 June 2017

  5. Research article

    Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment?

    Seronegative ocular myasthenia gravis (OMG) is diagnosed by ocular symptoms with supporting SFEMG, typically of frontalis or extensor digitorum muscles. We aimed to determine the sensitivity and specificity of...

    Goran Rakocevic, Mark Moster and Mary Kay Floeter

    BMC Neurology 2017 17:108

    Published on: 7 June 2017

  6. Research article

    Development and validation of a claims-based measure as an indicator for disease status in patients with multiple sclerosis treated with disease-modifying drugs

    Administrative healthcare claims data provide a mechanism for assessing and monitoring multiple sclerosis (MS) disease status across large, clinically representative “real-world” populations. The estimation of...

    Michael Munsell, Molly Frean, Joseph Menzin and Amy L. Phillips

    BMC Neurology 2017 17:106

    Published on: 5 June 2017

  7. Research article

    Association between total-Tau and brain atrophy one year after first-ever stroke

    Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural ...

    Hege Ihle-Hansen, Guri Hagberg, Brynjar Fure, Bente Thommessen, Morten W. Fagerland, Anne R. Øksengård, Knut Engedal and Per Selnes

    BMC Neurology 2017 17:107

    Published on: 5 June 2017

  8. Research article

    Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report

    Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emergi...

    A. Wallin, E. Kapaki, M. Boban, S. Engelborghs, D. M. Hermann, B. Huisa, M. Jonsson, M. G. Kramberger, L. Lossi, B. Malojcic, S. Mehrabian, A. Merighi, E. B. Mukaetova-Ladinska, G. P. Paraskevas, B. O. Popescu, R. Ravid…

    BMC Neurology 2017 17:102

    Published on: 23 May 2017

  9. Research article

    Association of fibrinogen level with early neurological deterioration among acute ischemic stroke patients with diabetes

    Diabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be as...

    Seong-Joon Lee, Ji Man Hong, Sung Eun Lee, Dae Ryong Kang, Bruce Ovbiagele, Andrew M. Demchuk and Jin Soo Lee

    BMC Neurology 2017 17:101

    Published on: 19 May 2017

  10. Study protocol

    The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol

    Aggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resona...

    Laura Gioia, Ana Klahr, Mahesh Kate, Brian Buck, Dariush Dowlatshahi, Thomas Jeerakathil, Derek Emery and Kenneth Butcher

    BMC Neurology 2017 17:100

    Published on: 19 May 2017

  11. Research article

    The association between lunar phase and intracranial aneurysm rupture: Myth or reality? Own data and systematic review

    It is a common belief in medical community that lunar phases have an impact on human health. A growing body of evidence indicates that lunar phases can predict the risk to develop acute neurological and vascul...

    Adomas Bunevicius, Agne Gendvilaite, Vytenis Pranas Deltuva and Arimantas Tamasauskas

    BMC Neurology 2017 17:99

    Published on: 19 May 2017

  12. Research article

    Clinical experience with transcutaneous supraorbital nerve stimulation in patients with refractory migraine or with migraine and intolerance to topiramate: a prospective exploratory clinical study

    Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a...

    Michail Vikelis, Emmanouil V. Dermitzakis, Konstantinos C. Spingos, Georgios G. Vasiliadis, George S. Vlachos and Evaggelia Kararizou

    BMC Neurology 2017 17:97

    Published on: 18 May 2017

  13. Case report

    Case report: a novel frameshift mutation in the mitochondrial cytochrome c oxidase II gene causing mitochondrial disorder

    Mitochondrial cytochrome c oxidase 2, MT-CO2, encodes one of the three subunits, which form the catalytic core of cytochrome c oxidase (COX), complex IV. Mutations in MT-CO2 are rare a...

    Laura Kytövuori, Mikko Kärppä, Hannu Tuominen, Johanna Uusimaa, Markku Saari, Reetta Hinttala and Kari Majamaa

    BMC Neurology 2017 17:96

    Published on: 18 May 2017

  14. Research article

    Sex differences underlying orofacial varicella zoster associated pain in rats

    Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (H...

    Crystal Stinson, Mohong Deng, Michael B Yee, Larry L. Bellinger, Paul R. Kinchington and Phillip R. Kramer

    BMC Neurology 2017 17:95

    Published on: 17 May 2017

  15. Research article

    Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study

    To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD).

    Tomohiro Kaneta, Omi Katsuse, Takamasa Hirano, Matsuyoshi Ogawa, Ayako Shihikura-Hino, Keisuke Yoshida, Toshinari Odawara, Yoshio Hirayasu and Tomio Inoue

    BMC Neurology 2017 17:91

    Published on: 15 May 2017

  16. Case report

    A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation

    Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to autoimmune disorder. Polymyositis is a common n...

    Masahiko Fukatsu, Takenobu Murakami, Hiroshi Ohkawara, Shunichi Saito, Kazuhiko Ikeda, Suguru Kadowaki, Itaru Sasaki, Mari Segawa, Tomoko Soeda, Akihiko Hoshi, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Kazuei Ogawa, Yoshihiro Sugiura, Hitoshi Ohto, Yasuchika Takeishi…

    BMC Neurology 2017 17:93

    Published on: 15 May 2017

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