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Table 1 Efficacy, tolerability and patient satisfaction of co-enzyme Q10 and amitriptyline in the treatment of cyclic vomiting syndrome

From: Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study

  Amitriptyline Co-enzyme Q10
  Pediatric Onset1<18 y Adult Onset ≥18 y All Subjects Pediatric Onset1<18 y Adult Onset ≥18 y All Subjects
Episode Frequency 2 62/113 26/49 88/162 10/17 1/5 11/22
  55% 53% 54% 59% 20% 50%
Episode Duration 2 59/112 19/43 78/155 5/16 3/6 8/22
  53% 44% 50% 31% 50% 36%
Number of Emesis 2 52/110 6/16 70/154 6/16 2/4 8/20
  47% 41% 45% 38% 50% 40%
Nausea Severity 2 47/111 21/46 68/157 7/18 4/7 11/25
  42% 46% 43% 39% 57% 40%
Episode Improvement 3 88/123 39/54 127/177 12/18 5/7 17/25
  72% 72% 72% 67% 71% 68%
Side Effects Reported 72/139 30/63 102/202 0/20 0/8 0/28
  52% 48% 50% 0% 0% 0%
Discontinued Therapy Due to Side Effects 29/137 13/61 42/198 0/20 0/8 0/28
  21% 21% 21% 0% 0% 0%
Subject Statement of Risks V. Benefits 4 49/94 14/40 63/134 13/16 4/6 17/22
  52% 35% 47% 81% 67% 77%
Subjects' Recommendation 5 65/103 23/39 88/142 12/19 4/6 16/25
  63% 59% 62% 63% 67% 64%
Subject on Therapy at Time of Survey 68/111 30/48 98/159 14/19 6/7 20/26
  61% 63% 62% 74% 86% 77%
  1. 1The number of adolescent-onset cases was small, so the data were combined with the child-onset data.
  2. 2Proportion reporting a 50% reduction in this parameter
  3. 3Proportion reporting a 50% reduction in at least one of the above four parameters
  4. 4"Do you believe that the improvement you receive of [inset treatment name], if any, justified the side effects that you experienced?" - proportion answering as "yes, strongly" or "yes", as opposed to "sort of equal/not sure", "no" or "no, strongly".
  5. 5"Would you recommend [inset treatment name] to a friend or relative with CVS?" -- proportion answering as per 4above.