Table 14 (10) The Estimated Prevalence and the Number of Loci (n) for susceptible genotypes that include the HLA DRB1*1501 allele.
From: The genetic basis of multiple sclerosis: a model for MS susceptibility
Estimated Number of Susceptibility Genes Required (n) for all Loci | |||||||
|---|---|---|---|---|---|---|---|
11 | 12 | 13 | 14 | 15 | 16 | 17 | |
Frequency of Susceptibility (r) | Estimated Prevalence of HLA DRB1*1501 in an MS Population (unadjusted; OR ≈ 2.21) | ||||||
r = 0.25 | 0.25 | 0.26 | 0.24 - 0.26 | 0.24 - 0.26 | 0.24 - 0.26 | 0.25 | 0.25 |
r = 0.33 | 0.32 - 0.37 | 0.33 - 0.39 | 0.35 | 0.32 - 0.36 | 0.33 - 0.37 | 0.34 - 0.38 | 0.34 |
r = 0.5 | 0.39 - 0.42 | 0.38 - 0.44 | 0.39 - 0.42 | 0.39 - 0.41 | 0.39 - 0.42 | 0.38 - 0.41 | 0.40 - 0.42 |
r = 1 | 0.42 - 0.44 | 0.41 - 0.43 | 0.41 - 0.44 | 0.41 - 0.43 | 0.41 - 0.43 | 0.42 - 0.44 | 0.41 - 0.43 |
r = 2 | 0.42 - 0.44 | 0.41 - 0.44 | 0.41 - 0.44 | 0.42 - 0.43 | 0.41 - 0.43 | 0.42 - 0.43 | 0.42 - 0.43 |
r = 4 | 0.42 - 0.44 | 0.42 - 0.44 | 0.42 - 0.44 | 0.41 - 0.43 | 0.42 - 0.43 | 0.42 - 0.43 | 0.42 - 0.43 |
r = 8 | 0.42 - 0.44 | 0.42 - 0.44 | 0.41 - 0.43 | 0.42 - 0.43 | 0.42 - 0.43 | 0.41 - 0.43 | 0.42 - 0.43 |
r = 16 | 0.42 - 0.44 | 0.42 - 0.44 | 0.42 - 0.43 | 0.42 - 0.43 | 0.42 - 0.43 | 0.42 - 0.43 | 0.41 - 0.43 |
Frequency of Susceptibility (r) | Odd Ratios for Recessive non-HLA DRB1 Loci (after adjustment of HLA to OR = 3.34) | ||||||
r = 0.25 | 1.21 | 1.23 | 1.05 - 1.23 | 1.05 - 1.27 | 1.07 - 1.29 | 1.07 | 1.08 |
r = 0.33 | 1.57 - 2.03 | 1.66 - 2.15 | 1.66 - 2.15 | 1.51 - 1.82 | 1.57 - 1.91 | 1.64 - 2.00 | 1.70 |
r = 0.5 | 1.88 - 2.15 | 1.79 - 2.30 | 1.79 - 2.30 | 1.82 - 2.01 | 1.91 - 2.12 | 1.84 - 2.01 | 1.92 - 2.11 |
r = 1 | 1.86 - 2.05 | 1.82 - 1.98 | 1.82 - 1.98 | 1.82 - 1.96 | 1.85 - 1.98 | 1.88 - 2.01 | 1.84 - 1.96 |
r = 2 | 1.75 - 1.85 | 1.73 - 1.85 | 1.73 - 1.85 | 1.75 - 1.83 | 1.74 - 1.84 | 1.74 - 1.84 | 1.75 - 1.82 |
r = 4 | 1.65 - 1.78 | 1.66 - 1.75 | 1.66 - 1.75 | 1.65 - 1.74 | 1.66 - 1.74 | 1.66 - 1.74 | 1.66 - 1.73 |
r = 8 | 1.60 - 1.69 | 1.60 - 1.69 | 1.60 - 1.69 | 1.60 - 1.67 | 1.60 - 1.67 | 1.60 - 1.67 | 1.61 - 1.66 |
r = 16 | 1.56 - 1.64 | 1.56 - 1.64 | 1.56 - 1.64 | 1.56 - 1.63 | 1.56 - 1.62 | 1.57 - 1.62 | 1.56 - 1.62 |