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Table 14 (10) The Estimated Prevalence and the Number of Loci (n) for susceptible genotypes that include the HLA DRB1*1501 allele.

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

  Estimated Number of Susceptibility Genes Required (n) for all Loci
  11 12 13 14 15 16 17
Frequency of Susceptibility (r) Estimated Prevalence of HLA DRB1*1501 in an MS Population (unadjusted; OR ≈ 2.21)
r = 0.25 0.25 0.26 0.24 - 0.26 0.24 - 0.26 0.24 - 0.26 0.25 0.25
r = 0.33 0.32 - 0.37 0.33 - 0.39 0.35 0.32 - 0.36 0.33 - 0.37 0.34 - 0.38 0.34
r = 0.5 0.39 - 0.42 0.38 - 0.44 0.39 - 0.42 0.39 - 0.41 0.39 - 0.42 0.38 - 0.41 0.40 - 0.42
r = 1 0.42 - 0.44 0.41 - 0.43 0.41 - 0.44 0.41 - 0.43 0.41 - 0.43 0.42 - 0.44 0.41 - 0.43
r = 2 0.42 - 0.44 0.41 - 0.44 0.41 - 0.44 0.42 - 0.43 0.41 - 0.43 0.42 - 0.43 0.42 - 0.43
r = 4 0.42 - 0.44 0.42 - 0.44 0.42 - 0.44 0.41 - 0.43 0.42 - 0.43 0.42 - 0.43 0.42 - 0.43
r = 8 0.42 - 0.44 0.42 - 0.44 0.41 - 0.43 0.42 - 0.43 0.42 - 0.43 0.41 - 0.43 0.42 - 0.43
r = 16 0.42 - 0.44 0.42 - 0.44 0.42 - 0.43 0.42 - 0.43 0.42 - 0.43 0.42 - 0.43 0.41 - 0.43
Frequency of Susceptibility (r) Odd Ratios for Recessive non-HLA DRB1 Loci (after adjustment of HLA to OR = 3.34)
r = 0.25 1.21 1.23 1.05 - 1.23 1.05 - 1.27 1.07 - 1.29 1.07 1.08
r = 0.33 1.57 - 2.03 1.66 - 2.15 1.66 - 2.15 1.51 - 1.82 1.57 - 1.91 1.64 - 2.00 1.70
r = 0.5 1.88 - 2.15 1.79 - 2.30 1.79 - 2.30 1.82 - 2.01 1.91 - 2.12 1.84 - 2.01 1.92 - 2.11
r = 1 1.86 - 2.05 1.82 - 1.98 1.82 - 1.98 1.82 - 1.96 1.85 - 1.98 1.88 - 2.01 1.84 - 1.96
r = 2 1.75 - 1.85 1.73 - 1.85 1.73 - 1.85 1.75 - 1.83 1.74 - 1.84 1.74 - 1.84 1.75 - 1.82
r = 4 1.65 - 1.78 1.66 - 1.75 1.66 - 1.75 1.65 - 1.74 1.66 - 1.74 1.66 - 1.74 1.66 - 1.73
r = 8 1.60 - 1.69 1.60 - 1.69 1.60 - 1.69 1.60 - 1.67 1.60 - 1.67 1.60 - 1.67 1.61 - 1.66
r = 16 1.56 - 1.64 1.56 - 1.64 1.56 - 1.64 1.56 - 1.63 1.56 - 1.62 1.57 - 1.62 1.56 - 1.62
  1. (Bold and underlined as designated for "Closeness of Fit" calculations in Table 8)