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Table 4 (4a) The Estimated total number of non-HLA susceptibility genes (x) based on the number of such genes necessary for MS to develop (n), and the frequency of susceptibility at the non-HLA susceptibility loci in the population (Pt0 = Pt1).

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

  Number of Susceptibility Genes Required (n)
  5 10 11 12 13 14 15
Frequency of Susceptibility (r) Estimated Total Number of non-HLA Susceptibility Genes (x)
r = 0.25 5 11 12 13 14-15 15-16 16-17
r = 0.33 6 12 13-14 14-15 16 17-18 18-19
r = 0.5 7 14-15 16-17 17-19 19-20 21-22 22-23
r = 1 11-12 23-25 25-27 28-30 30-32 33-35 35-37
r = 2 18-22 40-44 45-48 49-53 53-57 58-61 62-66
r = 4 35-42 75-83 83-91 92-99 100-107 108-116 116-124
r = 8 67-82 146-161 162-177 177-193 193-208 209-224 225-240
r = 16 131-162 287-317 318-348 349-379 380-410 411-441 442-472
Frequency of Susceptibility (r) Estimated Prevalence (Target = 0.1 - 0.2%)
r = 0.25 11.5% 12.7% 12.7% 12.4% 12.3 - 13.2% 12.1 - 13.2% 12.0 - 13.1%
r = 0.33 7.5% 5.2% 4.4 - 6.7% 3.7 - 5.9% 5.1% 4.4 - 6.4% 3.8 - 5.7%
r = 0.5 3.5% 1.2 - 2.0% 1.4 - 2.1% 0.9 - 2.2% 1.1 - 1.6% 1.2 - 1.7% 0.8 - 1.2%
r = 1 1.8 - 2.4% 0.6 - 1.0% 0.4 - 0.7% 0.4 - 0.7% 0.28 - 0.48% 0.27 - 0.45% 0.19 - 0.33%
r = 2 1.1 - 2.0% 0.3 - 0.6% 0.28 - 0.43% 0.21 - 0.37% 0.16 - 0.28% 0.14 - 0.21% 0.10 - 0.18%
r = 4 1.0 - 1.9% 0.26 - 0.47% 0.20 - 0.36% 0.16 - 0.27% 0.12 - 0.21% 0.10 - 0.17% 0.07 - 0.13%
r = 8 1.0 - 1.8% 0.24 - 0.42% 0.18 - 0.32% 0.14 - 0.25% 0.11 - 0.19% 0.08 - 0.14% 0.06 - 0.11%
r = 16 0.9 - 1.7% 0.23 - 0.40% 0.17 - 0.30% 0.13 - 0.23% 0.09 - 0.18% 0.08 - 0.13% 0.06 - 0.10%
   limit 1.27% 0.29% 0.22% 0.17% 0.13% 0.10% 0.07%
  1. Optimal solutions underlined.