Skip to main content

Table 4 (4a) The Estimated total number of non-HLA susceptibility genes (x) based on the number of such genes necessary for MS to develop (n), and the frequency of susceptibility at the non-HLA susceptibility loci in the population (Pt0 = Pt1).

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

 

Number of Susceptibility Genes Required (n)

 

5

10

11

12

13

14

15

Frequency of Susceptibility (r)

Estimated Total Number of non-HLA Susceptibility Genes (x)

r = 0.25

5

11

12

13

14-15

15-16

16-17

r = 0.33

6

12

13-14

14-15

16

17-18

18-19

r = 0.5

7

14-15

16-17

17-19

19-20

21-22

22-23

r = 1

11-12

23-25

25-27

28-30

30-32

33-35

35-37

r = 2

18-22

40-44

45-48

49-53

53-57

58-61

62-66

r = 4

35-42

75-83

83-91

92-99

100-107

108-116

116-124

r = 8

67-82

146-161

162-177

177-193

193-208

209-224

225-240

r = 16

131-162

287-317

318-348

349-379

380-410

411-441

442-472

Frequency of Susceptibility (r)

Estimated Prevalence (Target = 0.1 - 0.2%)

r = 0.25

11.5%

12.7%

12.7%

12.4%

12.3 - 13.2%

12.1 - 13.2%

12.0 - 13.1%

r = 0.33

7.5%

5.2%

4.4 - 6.7%

3.7 - 5.9%

5.1%

4.4 - 6.4%

3.8 - 5.7%

r = 0.5

3.5%

1.2 - 2.0%

1.4 - 2.1%

0.9 - 2.2%

1.1 - 1.6%

1.2 - 1.7%

0.8 - 1.2%

r = 1

1.8 - 2.4%

0.6 - 1.0%

0.4 - 0.7%

0.4 - 0.7%

0.28 - 0.48%

0.27 - 0.45%

0.19 - 0.33%

r = 2

1.1 - 2.0%

0.3 - 0.6%

0.28 - 0.43%

0.21 - 0.37%

0.16 - 0.28%

0.14 - 0.21%

0.10 - 0.18%

r = 4

1.0 - 1.9%

0.26 - 0.47%

0.20 - 0.36%

0.16 - 0.27%

0.12 - 0.21%

0.10 - 0.17%

0.07 - 0.13%

r = 8

1.0 - 1.8%

0.24 - 0.42%

0.18 - 0.32%

0.14 - 0.25%

0.11 - 0.19%

0.08 - 0.14%

0.06 - 0.11%

r = 16

0.9 - 1.7%

0.23 - 0.40%

0.17 - 0.30%

0.13 - 0.23%

0.09 - 0.18%

0.08 - 0.13%

0.06 - 0.10%

   limit

1.27%

0.29%

0.22%

0.17%

0.13%

0.10%

0.07%

  1. Optimal solutions underlined.