From: The genetic basis of multiple sclerosis: a model for MS susceptibility
Number of Susceptibility Genes Required (n) | |||||||
---|---|---|---|---|---|---|---|
5 | 10 | 11 | 12 | 13 | 14 | 15 | |
Frequency of Susceptibility (r) | Estimated Total Number of non-HLA Susceptibility Genes (x) | ||||||
r = 0.25 | 5 | 11 | 12 | 13 | 14-15 | 15-16 | 16-17 |
r = 0.33 | 6 | 12 | 13-14 | 14-15 | 16 | 17-18 | 18-19 |
r = 0.5 | 7 | 14-15 | 16-17 | 17-19 | 19-20 | 21-22 | 22-23 |
r = 1 | 11-12 | 23-25 | 25-27 | 28-30 | 30-32 | 33-35 | 35-37 |
r = 2 | 18-22 | 40-44 | 45-48 | 49-53 | 53-57 | 58-61 | 62-66 |
r = 4 | 35-42 | 75-83 | 83-91 | 92-99 | 100-107 | 108-116 | 116-124 |
r = 8 | 67-82 | 146-161 | 162-177 | 177-193 | 193-208 | 209-224 | 225-240 |
r = 16 | 131-162 | 287-317 | 318-348 | 349-379 | 380-410 | 411-441 | 442-472 |
Frequency of Susceptibility (r) | Estimated Prevalence (Target = 0.1 - 0.2%) | ||||||
r = 0.25 | 11.5% | 12.7% | 12.7% | 12.4% | 12.3 - 13.2% | 12.1 - 13.2% | 12.0 - 13.1% |
r = 0.33 | 7.5% | 5.2% | 4.4 - 6.7% | 3.7 - 5.9% | 5.1% | 4.4 - 6.4% | 3.8 - 5.7% |
r = 0.5 | 3.5% | 1.2 - 2.0% | 1.4 - 2.1% | 0.9 - 2.2% | 1.1 - 1.6% | 1.2 - 1.7% | 0.8 - 1.2% |
r = 1 | 1.8 - 2.4% | 0.6 - 1.0% | 0.4 - 0.7% | 0.4 - 0.7% | 0.28 - 0.48% | 0.27 - 0.45% | 0.19 - 0.33% |
r = 2 | 1.1 - 2.0% | 0.3 - 0.6% | 0.28 - 0.43% | 0.21 - 0.37% | 0.16 - 0.28% | 0.14 - 0.21% | 0.10 - 0.18% |
r = 4 | 1.0 - 1.9% | 0.26 - 0.47% | 0.20 - 0.36% | 0.16 - 0.27% | 0.12 - 0.21% | 0.10 - 0.17% | 0.07 - 0.13% |
r = 8 | 1.0 - 1.8% | 0.24 - 0.42% | 0.18 - 0.32% | 0.14 - 0.25% | 0.11 - 0.19% | 0.08 - 0.14% | 0.06 - 0.11% |
r = 16 | 0.9 - 1.7% | 0.23 - 0.40% | 0.17 - 0.30% | 0.13 - 0.23% | 0.09 - 0.18% | 0.08 - 0.13% | 0.06 - 0.10% |
limit | 1.27% | 0.29% | 0.22% | 0.17% | 0.13% | 0.10% | 0.07% |