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Table 5 (4b) The total number of non-HLA susceptibility genes (x) based on the number of such genes necessary for MS to develop (n), and the frequency of susceptibility at the non-HLA susceptibility loci in the population (Pt0 = Pt1).

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

  Total Number Susceptibility Genes Required (n)
  16 17 18 30 40 50 60
Frequency of Susceptibility (r) Estimated Total Number of non-HLA Susceptibility Genes (x)
r = 0.25 18 19 20 - 21 33-35 44-46 56-58 67-71
r = 0.33 19-20 21 22 - 23 36-38 49-51 61-64 74-80
r = 0.5 24-25 25 - 26 27 - 28 44-47 60-62 75-78 91-101
r = 1 37-39 40-42 42 - 44 71-75 95-100 120-124 144-166
r = 2 66-70 71-74 75 - 79 125-133 168-176 212-220 255-300
r = 4 124-132 132-140 140 - 148 234-250 316-331 397-413 478-569
r = 8 240-256 256 - 271 272 - 287 453-484 611-642 769-800 926-1109
r = 16 473-503 504 - 535 535 - 566 892-953 1202-1264 1512-1574 1823-2000
Frequency of Susceptibility (r) Estimated Prevalence (Target = 0.1 - 0.2%)
r = 0.25 13.1% 13.1% 13.0 - 13.3% 13.0 - 13.4% 13.1 - 13.4% 13.4% 13.4%
r = 0.33 3.2 - 5.0% 4.4% 3.8 - 5.6% 1.7 - 3.5% 1.6 -3.4% 1.0 - 3.1% 1.0 - 5.4%
r = 0.5 0.9 - 1.3% 0.6 - 1.0% 0.7 - 1.0% 0.10 - 0.35% 0.05 - 0.11% 0.01 - 0.05% 0.00 - 0.20%
r = 1 0.14 - 0.24% 0.14 - 0.23% 0.10 - 0.17% 0.00 - 0.03% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00%
r = 2 0.07 - 0.14% 0.07 - 0.10% 0.05 - 0.09% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00%
r = 4 0.06 - 0.10% 0.04 - 0.08% 0.03 - 0.06% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00%
r = 8 0.05 - 0.09% 0.04 - 0.07% 0.03 - 0.05% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00%
r = 16 0.05 - 0.08% 0.03 - 0.06% 0.03 - 0.05% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00% 0.00 - 0.00%
   limit 0.06% 0.04% 0.03% 0.00% 0.00% 0.00% 0.00%