The genetic basis of multiple sclerosis: a model for MS susceptibility

BMC Neurology

Table 5 (4b) The total number of non-HLA susceptibility genes (x) based on the number of such genes necessary for MS to develop (n), and the frequency of susceptibility at the non-HLA susceptibility loci in the population (Pt₀ = Pt₁).

	Total Number Susceptibility Genes Required (n)
	16	17	18	30	40	50	60
Frequency of Susceptibility (r)	Estimated Total Number of non-HLA Susceptibility Genes (x)
r = 0.25	18	19	20 - 21	33-35	44-46	56-58	67-71
r = 0.33	19-20	21	22 - 23	36-38	49-51	61-64	74-80
r = 0.5	24-25	25 - 26	27 - 28	44-47	60-62	75-78	91-101
r = 1	37-39	40-42	42 - 44	71-75	95-100	120-124	144-166
r = 2	66-70	71-74	75 - 79	125-133	168-176	212-220	255-300
r = 4	124-132	132-140	140 - 148	234-250	316-331	397-413	478-569
r = 8	240-256	256 - 271	272 - 287	453-484	611-642	769-800	926-1109
r = 16	473-503	504 - 535	535 - 566	892-953	1202-1264	1512-1574	1823-2000
Frequency of Susceptibility (r)	Estimated Prevalence (Target = 0.1 - 0.2%)
r = 0.25	13.1%	13.1%	13.0 - 13.3%	13.0 - 13.4%	13.1 - 13.4%	13.4%	13.4%
r = 0.33	3.2 - 5.0%	4.4%	3.8 - 5.6%	1.7 - 3.5%	1.6 -3.4%	1.0 - 3.1%	1.0 - 5.4%
r = 0.5	0.9 - 1.3%	0.6 - 1.0%	0.7 - 1.0%	0.10 - 0.35%	0.05 - 0.11%	0.01 - 0.05%	0.00 - 0.20%
r = 1	0.14 - 0.24%	0.14 - 0.23%	0.10 - 0.17%	0.00 - 0.03%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%
r = 2	0.07 - 0.14%	0.07 - 0.10%	0.05 - 0.09%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%
r = 4	0.06 - 0.10%	0.04 - 0.08%	0.03 - 0.06%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%
r = 8	0.05 - 0.09%	0.04 - 0.07%	0.03 - 0.05%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%
r = 16	0.05 - 0.08%	0.03 - 0.06%	0.03 - 0.05%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%	0.00 - 0.00%
limit	0.06%	0.04%	0.03%	0.00%	0.00%	0.00%	0.00%

ISSN: 1471-2377