Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica

BMC Neurology

Table 2 Lymphocyte subsets (%) on blood of patients with NMO and MS

PB measurements (%)	Lymphocyte subsets	NMO (n = 12)	MS (n = 24)	NC (n = 25)	P value
					NMO vs NC	MS vs NC	NMO vs MS
Lymphocyte		18.8 ± 1.8	25.7 ± 2.0	35.4 ± 1.8	<0.001*	0.001*	0.009*
CD3+	T cell	73.5 ± 2.6	70.2 ± 1.7	66.1 ± 1.7	0.039	0.071	0.486
CD3+CD4+	Th/Ti	40.8 ± 2.9	41.6 ± 2.2	38.8 ± 1.3	0.212	0.045	0.837
CD3+CD8+	Ts/Tc	31.5 ± 2.7	28.4 ± 1.7	26.4 ± 1.4	0.205	0.321	0.767
CD3+CD19+	B cell	15.4 ± 2.0	17.0 ± 1.2	17.3 ± 0.9	0.527	0.810	0.600
CD4+CD25+		16.8 ± 2.3	17.0 ± 1.4	11.4 ± 0.9	0.051	<0.001*	0.674
CD4+CD45RO+	Memory T	28.0 ± 2.4	27.1 ± 1.6	23.0 ± 0.9	0.039	0.007*	0.810
CD4+CD45RA+	Naïve T	22.9 ± 2.7	26.9 ± 2.0	25.8 ± 1.5	0.427	0.656	0.289
CD4+CXCR3+	Th1	23.9 ± 3.5	24.9 ± 2.4	19.6 ± 1.9	0.188	0.039	0.722
CD4+CCR5+	Th1	0.7 ± 0.2	1.0 ± 0.3	1.4 ± 0.3	0.112	0.062	0.730
CD4+CCR4+	Th2	25.2 ± 2.1	26.9 ± 1.9	26.4 ± 1.4	0.602	0.785	0.470
CD4+CCR3+	Th2	1.1 ± 0.2	0.9 ± 0.2	1.8 ± 0.2	0.022	0.001*	0.272
CD8+CXCR3+	Tc1	21.1 ± 4.1	18.3 ± 1.0	15.4 ± 1.9	0.183	0.020	0.844
CD8+CCR4+	Tc2	9.5 ± 2.4	6.9 ± 0.7	9.6 ± 0.9	0.355	0.017	0.952
CD4+CXCR3+/CD4+CCR4+	Th1/2	1.0 ± 0.1	1.0 ± 0.1	0.8 ± 0.1	0.122	0.023	0.908
CD4+CXCR3+/CD4+CCR3+	Th1/2	31.4 ± 9.4	23.1 ± 2.4	13.7 ± 1.9	0.035	0.007*	0.966
CD4+CCR5+/CD4+CCR4+	Th1/2	0.03 ± 0.01	0.03 ± 0.01	0.06 ± 0.01	0.093	0.041	0.646
CD4+CCR5+/CD4+CCR3+	Th1/2	0.7 ± 0.2	1.2 ± 0.3	0.8 ± 0.1	0.520	0.754	0.453
CD8+CXCR3+/CD8+CCR4+	Tc1/2	3.4 ± 0.6	3.4 ± 0.5	2.0 ± 0.3	0.056	<0.001*	0.738

Values indicate mean ± standard error, PB: peripheral blood, NMO: neuromyelitis optica, MS: multiple sclerosis, HC: healthy control, Th: helper Tcell, Ti: inducer T, Ts: suppressor T, Tc: cytotoxic T, CCR: CC chemokine receptor, CXCR: CXC chemokine receptor. *Statistically significantly even after multiple comparison adjustment.

ISSN: 1471-2377