Skip to main content

Advertisement

Table 2 Lymphocyte subsets (%) on blood of patients with NMO and MS

From: Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica

PB measurements (%) Lymphocyte subsets NMO (n = 12) MS (n = 24) NC (n = 25) P value   
      NMO vs NC MS vs NC NMO vs MS
Lymphocyte   18.8 ± 1.8 25.7 ± 2.0 35.4 ± 1.8 <0.001* 0.001* 0.009*
CD3+ T cell 73.5 ± 2.6 70.2 ± 1.7 66.1 ± 1.7 0.039 0.071 0.486
CD3+CD4+ Th/Ti 40.8 ± 2.9 41.6 ± 2.2 38.8 ± 1.3 0.212 0.045 0.837
CD3+CD8+ Ts/Tc 31.5 ± 2.7 28.4 ± 1.7 26.4 ± 1.4 0.205 0.321 0.767
CD3+CD19+ B cell 15.4 ± 2.0 17.0 ± 1.2 17.3 ± 0.9 0.527 0.810 0.600
CD4+CD25+   16.8 ± 2.3 17.0 ± 1.4 11.4 ± 0.9 0.051 <0.001* 0.674
CD4+CD45RO+ Memory T 28.0 ± 2.4 27.1 ± 1.6 23.0 ± 0.9 0.039 0.007* 0.810
CD4+CD45RA+ Naïve T 22.9 ± 2.7 26.9 ± 2.0 25.8 ± 1.5 0.427 0.656 0.289
CD4+CXCR3+ Th1 23.9 ± 3.5 24.9 ± 2.4 19.6 ± 1.9 0.188 0.039 0.722
CD4+CCR5+ Th1 0.7 ± 0.2 1.0 ± 0.3 1.4 ± 0.3 0.112 0.062 0.730
CD4+CCR4+ Th2 25.2 ± 2.1 26.9 ± 1.9 26.4 ± 1.4 0.602 0.785 0.470
CD4+CCR3+ Th2 1.1 ± 0.2 0.9 ± 0.2 1.8 ± 0.2 0.022 0.001* 0.272
CD8+CXCR3+ Tc1 21.1 ± 4.1 18.3 ± 1.0 15.4 ± 1.9 0.183 0.020 0.844
CD8+CCR4+ Tc2 9.5 ± 2.4 6.9 ± 0.7 9.6 ± 0.9 0.355 0.017 0.952
CD4+CXCR3+/CD4+CCR4+ Th1/2 1.0 ± 0.1 1.0 ± 0.1 0.8 ± 0.1 0.122 0.023 0.908
CD4+CXCR3+/CD4+CCR3+ Th1/2 31.4 ± 9.4 23.1 ± 2.4 13.7 ± 1.9 0.035 0.007* 0.966
CD4+CCR5+/CD4+CCR4+ Th1/2 0.03 ± 0.01 0.03 ± 0.01 0.06 ± 0.01 0.093 0.041 0.646
CD4+CCR5+/CD4+CCR3+ Th1/2 0.7 ± 0.2 1.2 ± 0.3 0.8 ± 0.1 0.520 0.754 0.453
CD8+CXCR3+/CD8+CCR4+ Tc1/2 3.4 ± 0.6 3.4 ± 0.5 2.0 ± 0.3 0.056 <0.001* 0.738
  1. Values indicate mean ± standard error, PB: peripheral blood, NMO: neuromyelitis optica, MS: multiple sclerosis, HC: healthy control, Th: helper Tcell, Ti: inducer T, Ts: suppressor T, Tc: cytotoxic T, CCR: CC chemokine receptor, CXCR: CXC chemokine receptor. *Statistically significantly even after multiple comparison adjustment.