Severe course of Lyme neuroborreliosis in an HIV-1 positive patient; case report and review of the literature

BMC Neurology

Table 1 Clinical data from all patients with LNB and HIV reported in literature.

Case no.*	Anti-retroviral	Antibiotic prophylaxis	Skin manifestations	Presentation	Treatment	Clinical recovery
1	none	none	Annular erythematous lesion	Several weeks later: fever, bilateral facial palsy	IV ceftriaxone 2 g/day 14 days	After treatment vast improvement 2 months, complete recovery
2	Zidovudine	none reported	Erythema	Headache, painful limbs, weight loss, pneumonia	Primairily: PO Azithromycin	Progression to neuroborreliosis
	Saquinavir				1 day 500 mg, 4 days 250 mg
	Zalcitabine			2 weeks later: fever, diplopia	IV ceftriaxone 2 g/day 14 days	Improved rapidly
3	Zidovudine	none reported	Erythematous lesion	4 weeks later:: radiculitis	IV ceftriaxone 2 g/day 15 days	Complete recovery
	Didanosine					18 months, no relapse
4	none	none reported	Multiple	Fever, chills, arthralgias	IV ceftotaxime 2 g TID 21 days	After treatment mild facial palsy
			Maculous erythemas	2 weeks later left facial palsy		6 months, slight hypokinesia face
5	Zidovudine	none	None	Altered gait for months	IV ceftriaxone 2 g/day 1 month	After treatment severe sequelae
	Lamivudine					3 years, no relapse
	Nevirapine

ISSN: 1471-2377