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Table 4 Multivariate Analysis of Factors Predicting Depression

From: Mood after stroke: a case control study of biochemical, neuro-imaging and socio-economic risk factors for major depression in stroke survivors

 

4A

(39 cases, 86 controls)

4B: (CT results)

(32 cases, 69 controls)

 

β

Adjusted OR

95% CI

p

β

Adjusted OR

95% CI

p

Matched Variables

        

Age

-0.03

0.97

0.93 - 1.02

0.2

-0.02

0.98

0.93 - 1.03

0.5

Total BI

0.03

0.97

0.84 - 1.11

0.5

-0.1

0.91

0.78 - 1.1

0.2

'Basic Model' Variables

        

Mean Arterial Pressure

0.05

1.05

1.01 - 1.09

0.016

0.05

1.06

1.01 - 1.1

0.016

Total Number of Strokes

0.67

2.0

1.2 - 3.2

0.033

0.59

1.8

1.1 - 3.0

0.024

PAD

1.7

5.4

1.4 - 20.8

0.014

1.5

4.4

0.99 - 19.5

0.052

Total MMSE

-0.3

0.74

0.63 - 0.88

< 0.001

-0.2

0.80

0.67 - 0.96

0.015

Folate/Homocysteine

        

Serum Folate*

-0.45

0.64

0.24 - 1.66

0.4

-1.12

0.33

0.1 - 1.05

0.06

Serum Homocysteine*

1.03

2.8

0.69 - 11.5

0.15

1.73

5.6

1.04 - 30.3

0.04

Serum Homocysteine* omitting PAD from model

1.25

3.5

1.0 - 12.7

0.055

2.01

7.5

1.5 - 36.7

0.013

Other Vascular RFs

        

Diabetes

-1.7

0.18

0.03 - 0.98

0.047

-2.8

0.06

0.01 - 0.66

0.02

AF

0.72

2.06

0.57 - 7.41

0.3

1.0

2.7

0.73 - 10.0

0.14

IHD

0.05

1.05

0.40 - 2.78

0.9

0.2

1.2

0.4 - 3.7

0.7

Smoking History

0.46

1.58

0.73 - 3.46

0.2

0.36

1.4

0.62 - 3.3

0.4

CT Scan Findings

        

Any abnormality visible

    

1.05

2.9

1.2 - 6.8

0.017

Discrete lesion visible

    

1.03

2.8

0.9 - 8.7

0.08

Total No. of lesions

    

0.39

1.5

0.71 - 3.1

0.3

Lesion location

(subcortical vs. cortical)

    

1.05

2.9

0.95 - 8.6

0.06

Size of the Largest Lesion

    

0.25

1.3

0.73 - 2.3

0.4

Lacunar Infarct(s) present

    

0.28

1.3

0.45 - 3.8

0.6

White Matter Changes

        

Overall WMC Score*

    

0.39

1.5

0.97 - 2.2

0.07

Basal Ganglia changes*

    

0.40

1.5

0.97 - 2.3

0.07

Frontal WMCs*

    

0.22

1.3

0.89 - 1.8

0.2

Parieto-occipital WMCs*

    

0.09

1.1

0.77 - 1.6

0.6

  1. OR: Odds ratio for depressed vs. control; CT: computed tomography; BI: Barthel Index,
  2. PAD: peripheral arterial disease, RF: risk factor; AF: atrial fibrillation; IHD: ischaemic heart disease; WMCs: white matter changes (includes diffuse ischaemic changes in basal ganglia)
  3. * Natural logarithmic transform used
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BMC Neurology

ISSN: 1471-2377

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