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Table 4 Multivariate Analysis of Factors Predicting Depression

From: Mood after stroke: a case control study of biochemical, neuro-imaging and socio-economic risk factors for major depression in stroke survivors

  4A
(39 cases, 86 controls)
4B: (CT results)
(32 cases, 69 controls)
  β Adjusted OR 95% CI p β Adjusted OR 95% CI p
Matched Variables         
Age -0.03 0.97 0.93 - 1.02 0.2 -0.02 0.98 0.93 - 1.03 0.5
Total BI 0.03 0.97 0.84 - 1.11 0.5 -0.1 0.91 0.78 - 1.1 0.2
'Basic Model' Variables         
Mean Arterial Pressure 0.05 1.05 1.01 - 1.09 0.016 0.05 1.06 1.01 - 1.1 0.016
Total Number of Strokes 0.67 2.0 1.2 - 3.2 0.033 0.59 1.8 1.1 - 3.0 0.024
PAD 1.7 5.4 1.4 - 20.8 0.014 1.5 4.4 0.99 - 19.5 0.052
Total MMSE -0.3 0.74 0.63 - 0.88 < 0.001 -0.2 0.80 0.67 - 0.96 0.015
Folate/Homocysteine         
Serum Folate* -0.45 0.64 0.24 - 1.66 0.4 -1.12 0.33 0.1 - 1.05 0.06
Serum Homocysteine* 1.03 2.8 0.69 - 11.5 0.15 1.73 5.6 1.04 - 30.3 0.04
Serum Homocysteine* omitting PAD from model 1.25 3.5 1.0 - 12.7 0.055 2.01 7.5 1.5 - 36.7 0.013
Other Vascular RFs         
Diabetes -1.7 0.18 0.03 - 0.98 0.047 -2.8 0.06 0.01 - 0.66 0.02
AF 0.72 2.06 0.57 - 7.41 0.3 1.0 2.7 0.73 - 10.0 0.14
IHD 0.05 1.05 0.40 - 2.78 0.9 0.2 1.2 0.4 - 3.7 0.7
Smoking History 0.46 1.58 0.73 - 3.46 0.2 0.36 1.4 0.62 - 3.3 0.4
CT Scan Findings         
Any abnormality visible      1.05 2.9 1.2 - 6.8 0.017
Discrete lesion visible      1.03 2.8 0.9 - 8.7 0.08
Total No. of lesions      0.39 1.5 0.71 - 3.1 0.3
Lesion location
(subcortical vs. cortical)
     1.05 2.9 0.95 - 8.6 0.06
Size of the Largest Lesion      0.25 1.3 0.73 - 2.3 0.4
Lacunar Infarct(s) present      0.28 1.3 0.45 - 3.8 0.6
White Matter Changes         
Overall WMC Score*      0.39 1.5 0.97 - 2.2 0.07
Basal Ganglia changes*      0.40 1.5 0.97 - 2.3 0.07
Frontal WMCs*      0.22 1.3 0.89 - 1.8 0.2
Parieto-occipital WMCs*      0.09 1.1 0.77 - 1.6 0.6
  1. OR: Odds ratio for depressed vs. control; CT: computed tomography; BI: Barthel Index,
  2. PAD: peripheral arterial disease, RF: risk factor; AF: atrial fibrillation; IHD: ischaemic heart disease; WMCs: white matter changes (includes diffuse ischaemic changes in basal ganglia)
  3. * Natural logarithmic transform used