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(1) age 18 years and older
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(2) suffering from severe fatigue (CIS-fatigue ≥ 35) [21]
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(3) ability to walk independently (ankle-foot orthoses and canes are accepted)
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(4) being able to exercise on a bicycle ergometer
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(5) being able to complete either type of intervention
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Exclusion criteria
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(1) cognitive impairment
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(2) insufficient mastery of the Dutch language
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(3) neurological or orthopedic co-morbidity interfering with the interventions or possibly influencing outcomes
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(4) pregnancy
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(5) use of psychotropic drugs (except simple sleeping medication)
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(6) severe cardiopulmonary disease (chest pain, arrhythmia, pacemaker, cardiac surgery, severe exertional dyspnea, emphysema)
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(7) epileptic seizures
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(8) poorly regulated diabetes mellitus or hypertension
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(9) clinical depression, as diagnosed with the Beck Depression Inventory for primary care (BDI-PC) [22, 23]
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