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Table 1 Clinical follow-up of the MS case from MS onset (1999) up to January 2010. Abbreviations and symbols in the text (Case Presentation)

From: Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report

Year

1999-2000

2001

2002

2003

2004

2005

2006

2007

2008

2009-2010

Non-epileptic MS relapses

1

0

1

0

1

0

0

1

1

0

Brain MRI activity

(new T2 or Gd + lesions or both)

+

-

+

-

-

n.d.

-

n.d.

+

-

EDSS score

-

0

1

1

2

2

2.5*

3*

4**

2.5*

MS therapy

-

-

GA

GA

GA

GA

GA

GA

GA

Natalizumab

Partial seizures

1 (onset)

1

4

4

6

8

7

8

10

4

Generalized seizures

1 (onset)

1

3

2

3

6

5

5

7

0

Status epilepticus

0

0

0

0

0

1

0

1

1

0

AEDs (daily dose in mg)

 

VPA 600

VPA 1000

VPA 1000

VPA 1000

VPA 1300

VPA 1000

KEP 3000

KEP 3000

KEP 1000

   

CBZ 300

CBZ 800

CBZ 1200

CBZ 1400

LMT§

OXC 2100

OXC 2400

GBP 900

       

TOP 250

 

GBP 900

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