Skip to main content

Advertisement

Table 3 Baseline Scores and Group Change in Behaviour after Treatment with Minocycline for 8 weeks

From: Open-label add-on treatment trial of minocycline in fragile X syndrome

  Baseline Group 8 Week Group Group Mean p1
Measure Mean +/- SD Mean +/- SD Change +/- SD  
VAS 19.32 7.67 34.40 18.48 15.58 20.25 .003
CGI 4.67 0.49 3.06 0.64 -1.61 0.78 < .001
ABC-C 2
   Irritability 22.11 7.23 7.74 4.82 -14.37 7.84 < .001
   Lethargy 15.37 10.44 11.47 6.28 -3.89 8.30 .065
   Stereotypy 7.95 5.34 3.79 3.07 -4.16 3.34 < .001
   Hyperactivity 17.42 10.43 11.11 7.06 -6.32 7.67 .002
   Inappropriate speech 7.42 4.00 4.79 2.68 -2.63 3.13 .002
   Total 70.26 26.03 38.90 17.78 -31.37 23.21 < .001
  1. 1 Significance with Bonferroni correction applied.
  2. 2 Negative values indicate a positive change.