Table 3 Baseline Scores and Group Change in Behaviour after Treatment with Minocycline for 8 weeks
From: Open-label add-on treatment trial of minocycline in fragile X syndrome
| Â | Baseline Group | 8 Week Group | Group Mean | p1 | |||
|---|---|---|---|---|---|---|---|
Measure | Mean | +/- SD | Mean | +/- SD | Change | +/- SD | Â |
VAS | 19.32 | 7.67 | 34.40 | 18.48 | 15.58 | 20.25 | .003 |
CGI | 4.67 | 0.49 | 3.06 | 0.64 | -1.61 | 0.78 | < .001 |
ABC-C 2 | |||||||
   Irritability | 22.11 | 7.23 | 7.74 | 4.82 | -14.37 | 7.84 | < .001 |
   Lethargy | 15.37 | 10.44 | 11.47 | 6.28 | -3.89 | 8.30 | .065 |
   Stereotypy | 7.95 | 5.34 | 3.79 | 3.07 | -4.16 | 3.34 | < .001 |
   Hyperactivity | 17.42 | 10.43 | 11.11 | 7.06 | -6.32 | 7.67 | .002 |
   Inappropriate speech | 7.42 | 4.00 | 4.79 | 2.68 | -2.63 | 3.13 | .002 |
   Total | 70.26 | 26.03 | 38.90 | 17.78 | -31.37 | 23.21 | < .001 |