Overnight switch from ropinirole to transdermal rotigotine patch in patients with Parkinson disease

BMC Neurology

Table 4 Rotigotine plasma concentrations at end of treatment

Daily rotigotine dose	n≧LOQ	ng/mL (unconjugated)	ng/mL (total)	Ratio (total rotigotine/ unconjugated rotigotine)
2 mg/24 hr	14	0.265 ± 0.146	1.995 ± 0.736	8.447 ± 2.919
4 mg/24 hr	24	0.559 ± 0.236	4.157 ± 1.534	7.922 ± 2.753
6 mg/24 hr	27	0.928 ± 1.005	6.620 ± 3.962	8.802 ± 4.871
8 mg/24 hr	23	1.215 ± 0.790	7.433 ± 4.423	6.968 ± 3.071

Plus-minus values are mean ± SD (Standard Deviation).
LOQ = limit of quantification (0.01 ng/mL for unconjugated Rotigotine, 0.01 ng/mL for total Rotigotine)
Note: Values below LOQ were replaced by 0 in calculations (Mean, SD, CV, Med, Min, Max)

ISSN: 1471-2377