Typical spectrum and regions of interest. A. Proton spectrum of a control subject in M1 showing the peaks corresponding to the metabolites of interest, creatine (Cr), myo-inositol (mI), glutamate (Glu), and N-acetylaspartate (NAA). Concentrations are derived from the area under the peaks. B. Regions of interest (ROI) for MRS data acquisition depicted in the sagittal, coronal, and axial planes in the dorsolateral prefrontal cortex (DLPFC) (middle; 16 mm × 16 mm × 16 mm), and C. primary motor cortex (M1) (bottom; 16 mm × 20 mm × 32 mm). Spectra were recorded in both the left and right hemispheres.