| | |
RLS + ICBs
|
RLSnonICBs
|
p-value
|
|---|
|
Total number
| |
n = 10
|
n = 130
| |
|
Female gender
| |
n = 10 (100%)
|
n = 88 (67.6%)
|
0.04
|
|
Mean age of RLS onset in years (SD)
| |
46.6 (10.1)
|
57 (15.9)
|
0.04
|
|
Medication
|
Dopaminergic
|
n = 10 (100%)
|
n = 122 (93.8%)
|
0.4
|
| |
Other
|
n = 0 (0%)
|
n = 8 (6.2%)
| |
|
Da type
|
Ropinirole
|
n = 3 (37.5%)
|
n = 29 (29.8%)
|
0.6
|
| |
Pramipexole
|
n = 3 (37.5%)
|
n = 43 (44.3%)
|
0.5
|
| |
Other
|
n = 2 (25%)
|
n = 25 (25.7%)
|
0.3
|
|
Mean DA dose as LEDD mg/d *(SD)
| |
63.7 (52.7)
|
26.7 (26.4)
|
0.001
|
|
FHx alcohol use disorder
| |
n = 3 (30%)
|
n = 12 (9.2%)
|
0.09
|
|
FHx gambling disorder
| |
n = 2 (20%)
|
n = 2 (2%)
|
0.02
|
|
Hx experimental drug use
| |
n = 5 (50%)
|
n = 10 (7.9%)
|
0.002
|
|
Cigarettes smoked daily
|
0
|
n = 5 (50%)
|
n = 81 (62.3%)
|
0.19
|
| |
1-10
|
n = 0 (0%)
|
n = 10 (13%)
| |
| |
11-20
|
n = 3 (30%)
|
n = 13 (10%)
| |
| |
21-29
|
n = 0 (0%)
|
n = 6 (6%)
| |
| |
> 30
|
n = 2 (20%)
|
n = 10 (13%)
| |
|
Alcohol daily glasses
|
0
|
n = 8 (80%)
|
n = 70/118 (59.3%)
|
0.18
|
| |
1-7
|
n = 2 (20%)
|
n = 41/118 (34.8%)
| |
| |
8-14
|
n = 0 (0%)
|
n = 5/118 (4.2%)
| |
| |
15-21
|
n = 0 (0%)
|
n = 2/118 (1.7%)
| |
| |
> 22
|
n = 0 (0%)
|
n = 0 (0%)
| |
|
Mean novelty seeking score (SD)
| |
20.8 (5.3)
|
18 (5.5)
|
0.13
|
- *Calculation of Levodopa Daily Dose Equivalent (23); Abbreviations: RLS = Restless Legs Syndrome; ICBs = Impulse control behaviors; SD = standard deviation; DA = dopamine agonist; LEDD = levodopa dose equivalent; FHx = Family history; Hx = history; cut-off for significance: p < 0.05
