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Table 2 Comparison of cryptococcal meningoencephalitis patients with and without acute/subacute cerebral infarction

From: Acute/subacute cerebral infarction (ASCI) in HIV-negative adults with cryptococcal meningoencephalitis (CM): a MRI-based follow-up study and a clinical comparison to HIV-negative CM adults without ASCI

Characteristics with ASCI (n = 7) without ASCI (n = 30) p-value
Median age; range (years) 71 (46-78) 55 (19-82) 0.033 *
Male 4 21 0.659
Female 3 9  
Underlying conditions    
   Diabetes mellitus 3 2 0.037 *
   Liver disease 3 3 0.068
   Hypertension 1 6 1.000
Clinical manifestation    
   Fever 5 15 0.113
   Altered consciousness 7 15 0.028 *
   Seizure 1 6 1.000
   Previous stroke 2 0 0.032 *
Hydrocephalus 4 11 0.408
Positive CSF India ink staining 0 10/27 0.145
Positive CSF culture 4 20/28 0.652
CSF data median (range)*    
   WBC count (10 9 /L) 144 (33-160) 136 (0-980) 0.575
   Glucose level (mmol/L) 26.5 (14-53) 24 (0-255) 0.827
   Glucose ratio 0.16 (0.07-0.31) 0.19 (0-0.96) 0.731
   Total protein level (g/L) 232.5 (113-431) 106 (55-1626) 0.131
   Lactate level (mmol/dL) 44.95 (31-67) 47.6 (9-97) 0.687
   Cryptococcus antigen 1:384 (1:4-1:1024) 1:1024 (1:4-1:4096) 0.265
Prognosis    
   Poor 7 11 0.003
  1. CSF = cerebrospinal fluid; WBC = white blood cell; * = p < 0.05