Skip to main content

Table 1 General characteristics and plasma levels of 24S-OH-Chol in patients with Late Onset Alzheimer's Disease (LOAD), Vascular Dementia (VD), Cognitive Impairment No Dementia (CIND), and in older controls.

From: Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study

Parameter LOAD VD CIND Controls
  (n. 60) (n. 35) (n. 25) (n. 40)
Age (years)* 78 ± 5.5 77 ± 7.6 74 ± 8.2 73 ± 8.7
Female gender ^ 78,00% 53,00% 60,00% 68,00%
MMSE score (mean/SD)* 21.3 ± 3.8 21.7 ± 3.9 25 ± 3.1 28 ± 2
Barthel index § 82.5/100 79/100 96/100 96/100
GDS 5.7/15 5.3/15 6.3/15 6.2/15
Tot. Chol. (mg/dL) 210 ± 42 204 ± 32 207 ± 43 215 ± 28
Albumin (g/dL) 4.14 ± 0.38 4.11 ± 0.37 4.08 ± 0.34 4.22 ± 0.31
Hypertension 67,00% 83,00% 63,00% 67,00%
Diabetes 15,00% 34.5% 18,00% 19,00%
CHD ^ 16,00% 34.5% 12,00% 9.5%
24S-OH-Chol (ng/ml)° 51.0 (42.0-64.7) 39.1 (36.0-46.5) 47.0 (42.6-56.3) 46.3 (37.5-52.7)
Brain atrophy ^^ 84% 53% 51% 47%
Single lacune ^^ 5% 22% 7% 6.5%
Multiple lacunes ^^ 0% 55% 20% 10%
Cortical infarcts ^^ 0% 23% 11% 6%
  1. * ANOVA (model P < 0.001) Fisher's least significant difference (LSD) post-hoc test: C vs LOAD p < 0.01; C vs VD p < 0.05; VD vs LOAD and CIND p < 0.005
  2. § ANOVA (model P < 0.001) LSD p < 0.05 C and CIND vs LOAD and VD
  3. ^Chi square test p < 0.05; ^^Chi square test p < 0.001
  4. ° ANOVA (model P < 0.001) LSD p < 0.01 LOAD vs C; p < 0.05 VD vs C and CIND; p < 0.01 for LOAD vs VD
  5. MMSE: mini mental state examination; GDS: geriatric depression scale; CHD: coronary heart disease. For 24S-OH-Chol: median (interquartile range)