|
MRI Parameter
|
---|
|
T2 lesions
|
T1 Gd+ lesions
|
T1 black holes
|
---|
Lesion volume, mm3
|
Baseline
|
Year 3
|
Baseline
|
Year 3
|
Baseline
|
Year 3
|
---|
N
|
158
|
158
|
154
|
154
|
156
|
156
|
Mean (SD)
|
5990.1 (7111.6)
|
5345.9 (6755.3)
|
73.8 (252.1)
|
25.6 (125.5)
|
1263.1 (2430.6)
|
1185.4 (2520.7)
|
Median
|
3378.5
|
2825.0
|
0.0
|
0.0
|
436.3
|
341.9
|
Q1, Q3
|
1052.9, 7358.5
|
782.0, 6918.5
|
0.0, 0.0
|
0.0, 0.0
|
76.5, 1189.2
|
67.9, 1160.0
|
Absolute change, mm
3
|
N
|
158
|
154
|
156
|
Mean (SD)
|
−644.2 (3072.1)
|
−48.2 (269.3)*
|
−77.7 (1056.8)
|
Median
|
−135.6
|
0.0
|
0.0
|
Q1, Q3
|
−719.8, 86.7
|
0.0, 0.0
|
−89.5, 73.4
|
Percentage change
†
|
N
|
158
|
34
|
132
|
Mean (SD)
|
−7.6 (34.1)c
|
−60.5 (149.4)‡
|
0.3 (67.8)
|
Median
|
−7.3
|
−100.0
|
−4.7
|
Q1, Q3
|
−23.8, 4.0
|
−100.0, −100.0
|
−32.1, 19.5
|
- Gd+, gadolinium-enhancing; IFN, interferon.
- *P = 0.0034 vs baseline; Wilcoxon signed rank test.
-
†Percentage change was not calculated for patients with a lesion volume of 0 mm3 at baseline.
-
‡
P < 0.0001 vs baseline; Wilcoxon signed rank test.