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Table 1 Change in MRI parameters from baseline to Year 3 (pooled treatment groups)

From: Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon β-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) study

  MRI Parameter
  T2 lesions T1 Gd+ lesions T1 black holes
Lesion volume, mm3 Baseline Year 3 Baseline Year 3 Baseline Year 3
   N 158 158 154 154 156 156
   Mean (SD) 5990.1 (7111.6) 5345.9 (6755.3) 73.8 (252.1) 25.6 (125.5) 1263.1 (2430.6) 1185.4 (2520.7)
   Median 3378.5 2825.0 0.0 0.0 436.3 341.9
   Q1, Q3 1052.9, 7358.5 782.0, 6918.5 0.0, 0.0 0.0, 0.0 76.5, 1189.2 67.9, 1160.0
Absolute change, mm 3
   N 158 154 156
   Mean (SD) −644.2 (3072.1) −48.2 (269.3)* −77.7 (1056.8)
   Median −135.6 0.0 0.0
   Q1, Q3 −719.8, 86.7 0.0, 0.0 −89.5, 73.4
Percentage change
   N 158 34 132
   Mean (SD) −7.6 (34.1)c −60.5 (149.4) 0.3 (67.8)
   Median −7.3 −100.0 −4.7
   Q1, Q3 −23.8, 4.0 −100.0, −100.0 −32.1, 19.5
  1. Gd+, gadolinium-enhancing; IFN, interferon.
  2. *P = 0.0034 vs baseline; Wilcoxon signed rank test.
  3. Percentage change was not calculated for patients with a lesion volume of 0 mm3 at baseline.
  4. P < 0.0001 vs baseline; Wilcoxon signed rank test.