Table 2 Change in MRI parameters from baseline to Year 3 by IFN β-1a dosage
MRI Parameter | ||||||
|---|---|---|---|---|---|---|
T2 lesion volume | T1 Gd+ lesion volume | T1 black hole volume | ||||
IFN β-1a, 22 μg sc tiw | IFN β-1a, 44 μg sc tiw | IFN β-1a, 22 μg sc tiw | IFN β-1a, 44 μg sc tiw | IFN β-1a, 22 μg sc tiw | IFN β-1a, 44 μg sc tiw | |
Absolute change, mm 3 | ||||||
N | 72 | 86 | 70 | 84 | 71 | 85 |
Mean (SD) | −174.9 (1609.8) | −1037.2 (3863.3) | −23.5 (198.5) | −68.8 (316.3) | 64.5 (608.5) | −196.5 (1311.9) |
Median | −81.6 | −169.7 | 0.0 | 0.0 | 0.0 | −25.3 |
Q1, Q3 | −654.5, 126.8 | −1133.3, 13.5 | 0.0, 0.0 | 0.0, 0.0 | −40.3, 92.5 | −209.4, 26.8 |
P value | 0.092 | 0.472 | 0.017 | |||
Percentage change | ||||||
N | 72 | 86 | 15* | 19* | 59* | 73* |
Mean (SD) | −4.5 (27.3) | −10.2 (38.9) | −54.2 (177.5) | −65.4 (127.9) | 10.3 (49.3) | −7.8 (79.1) |
Median | −3.4 | −12.1 | −100.0 | −100.0 | 1.5 | −16.1 |
Q1, Q3 | −14.5, 4.3 | −30.6, 2.8 | −100.0, −100.0 | −100.0, −100.0 | −10.6, 23.2 | −50.5, 19.0 |
P value | 0.025 | 0.495 | 0.002 | |||