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Table 1 Mean ± S.D of all the measured parameters, percentage changes of autistic values relative to controls, and significant levels between both groups.

From: Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia

Parameter

Group

N

Mean ± S.D.

Percentage change

P value

Total glutathione (μmol/L)

Control

20

8.28 ± 1.03

100.00

0.001

 

Autistic

20

4.46 ± 0.33

53.85

 

Oxidized glutathione (GSSG) (μmol/L)

Control

20

0.32 ± 0.06

100.00

0.001

 

Autistic

20

0.54 ± 0.17

170.84

 

GSH/GSSG

Control

20

26.07 ± 5.03

100.00

0.001

 

Autistic

20

8.03 ± 2.46

30.79

 

Glutathione reductase(U/L)

Control

20

60.19 ± 15.42

100.00

0.052

 

Autistic

20

70.25 ± 16.35

116.71

 

Glutathione S transferase (μmol/min/ml)

Control

20

0.73 ± 0.37

100.00

0.002

 

Autistic

20

0.42 ± 0.18

57.48

 

Peroxiredoxin 1 (ng/ml)

Control

20

20.25 ± 5.99

100.00

0.001

 

Autistic

20

40.75 ± 17.92

201.23

 

Peroxiredoxin 3 (ng/ml)

Control

20

24.30 ± 2.69

100.00

0.001

 

Autistic

20

43.05 ± 5.86

177.16

 

Thioredoxin 1 (ng/ml)

Control

20

44.71 ± 7.43

100.00

0.001

 

Autistic

20

74.70 ± 9.04

167.09

 

Thioredoxin reductase (mU/ml)

Control

20

1.83 ± 0.52

100.00

0.001

 

Autistic

20

3.37 ± 1.22

184.15

 
  1. Independent student's t-test between the control and autistic groups and percentage change in total glutathione level, oxidised glutathione (GSSG), GSH/GSSG, glutathione reductase, glutathione -S- transferase, peroxiredoxin 1, peroxiredoxin 3 level, thioredoxin 1, thioredoxin reductase (mU/ml).