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Table 3 Final model for the stepwise Cox hazard model analysis showing Hazard Ratio (with relative confidence intervals and p-values) for worsening in disability after the increase of IFNB dose.

From: Management of breakthrough disease in patients with multiple sclerosis: when an increasing of Interferon beta dose should be effective?

  HR 95% C.I. p-value
Male gender 1.68 0.88 - 2.13 0.1
Age at switch (each year) 0.98 0.94 - 1-02 0.3
Interaction term (relapse * active MRI scan at switch) 2.14 1.16 - 3.96 0.01
EDSS score at switch (each point) 1.77 1.39 - 2.26 < 0.001
IFNB type (Betaferon or Rebif 44) 0.83 0.28 - 2.85 0.7
  1. IFNB: Interferon Beta; EDSS: Expanded Disability Status Scale.