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Table 4 Overview of treatments

From: Algorithms for the diagnosis and treatment of restless legs syndrome in primary care

Drug Starting dose and maximum recommended dosage Time to full effective therapeutic dose Half-life Side effects
Levodopa 50 mg
200 mg
At first dose 1.5-2 hours Augmentation
Rebound
Ropinirole 0.25 mg
4 mg
4-10 days 6 hours Nausea, low blood pressure, dizziness, headache, nasal congestion
Pramipexole 0.125 mg
0.54 mg
At first dose 8-12 hours Nausea, low blood pressure, dizziness, headache, nasal congestion
Rotigotine 1-3 mg patches 1 week 5-7 hours Skin irritation, nausea, low blood pressure, dizziness, headache, nasal congestion
Pregabalin 25-300 mg 3-6 days 10 hrs Sleepiness, dizziness, headache, fluid retention
Clonazepam 0.50 mg
2.0 mg
First dose: effect mainly on sleep 30-40 hours Sleepiness, dizziness, morning drug hangover
Gabapentin 300 mg
2700 mg
3-6 days 5-7 hours Sleepiness, dizziness, fluid retention