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Table 5 Drugs that may exacerbate RLS

From: Algorithms for the diagnosis and treatment of restless legs syndrome in primary care

Diphenhydramine (and other over the counter cold remedies)
Metoclopramide
Prochlorperazine
Chlordiazepoxide
Traditional antipsychotics (phenothiazines)
Atypical neuroleptics (olanzapine and risperidone)
Antidepressants (especially norepinehrine or selective serotonin reuptake inhibitors)
Anticonvulsants (zonisamide, phenytoin, methsuximide)
Antihistamines
Opiods