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Table 1 Clinical studies of triptan + NSAID combinations in the treatment of migraine (published 1999-2009)

From: Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Authors/year of publication Study type Type of combination (dosage) Dosage regime
Krymchantowski et al. 1999 [24] retrospective clinical case series sumatriptan (100 mg) + tolfenamic acid 200 mg single dose/attack (number of treated attacks per patient not reported)
Krymchantowski 2000 [25] open-label study sumatriptan (100 mg) + naproxen sodium (550 mg) single dose (3 attacks treated)
Smith et al. 2005 [26] multicenter, randomized, double-blind, double-dummy, placebo-controlled, four-arm study sumatriptan (50 mg) + naproxen sodium (500 mg) sumatriptan (50 mg) naproxen sodium (500 mg) placebo single dose
Brandes et al. 2007 [27] two replicate, randomized, double-blind, single attack, parallel-group studies sumatriptan (85 mg) + naproxen sodium (500 mg) sumatriptan (85 mg) naproxen sodium (500 mg) placebo single dose
Lipton et al. 2009 [28] two identical randomized, placebo-controlled, crossover studies sumatriptan (85 mg) + naproxen sodium (500 mg) placebo single dose (4 attacks treated) report of 2 clinical studies
Krymchantowski & Barbosa 2002 [29] open label pilot study rizatriptan (10 mg) + rofecoxib (25 mg) rizatriptan (10 mg) single dose (3 attacks treated)
Krymchantowski & Bigal 2004 [30] randomized, open-label, cross-over study rizatriptan (10 mg) + tolfenamic acid (200 mg) rizatriptan (10 mg) + rofecoxib (50 mg) rizatriptan (10 mg) single dose (2 attacks treated)
Krymchantowski et al. 2006 [31] double-blind, randomized, cross-over study rizatriptan (10 mg) + trimebutine (200 mg) rizatriptan (10 mg) single dose (2 attacks treated)
Freitag et al. 2008 [32] randomized, double-blind, placebo-controlled study rizatriptan (10 mg) + acetaminophen (1000 mg) rizatriptan (10 mg) acetaminophen (1000 mg) placebo single dose
Schoenen et al. 2008 [33] multicenter, double-blind, double-dummy, cross-over pilot study almotriptan (12.5 mg) + aceclofenac (100 mg) almotriptan (12.5 mg) + placebo single dose