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Table 1 Clinical studies of triptan + NSAID combinations in the treatment of migraine (published 1999-2009)

From: Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Authors/year of publication Study type Type of combination (dosage) Dosage regime
Krymchantowski et al. 1999 [24] retrospective clinical case series sumatriptan (100 mg)
+ tolfenamic acid 200 mg
single dose/attack (number of treated attacks per patient not reported)
Krymchantowski 2000 [25] open-label study sumatriptan (100 mg)
+ naproxen sodium (550 mg)
single dose
(3 attacks treated)
Smith et al. 2005 [26] multicenter, randomized, double-blind, double-dummy, placebo-controlled, four-arm study sumatriptan (50 mg)
+ naproxen sodium (500 mg)
sumatriptan (50 mg)
naproxen sodium (500 mg)
placebo
single dose
Brandes et al. 2007 [27] two replicate, randomized, double-blind, single attack, parallel-group studies sumatriptan (85 mg)
+ naproxen sodium (500 mg)
sumatriptan (85 mg)
naproxen sodium (500 mg)
placebo
single dose
Lipton et al. 2009 [28] two identical randomized, placebo-controlled, crossover studies sumatriptan (85 mg)
+ naproxen sodium (500 mg)
placebo
single dose
(4 attacks treated)
report of 2 clinical studies
Krymchantowski & Barbosa 2002 [29] open label pilot study rizatriptan (10 mg)
+ rofecoxib (25 mg)
rizatriptan (10 mg)
single dose
(3 attacks treated)
Krymchantowski & Bigal 2004 [30] randomized, open-label, cross-over study rizatriptan (10 mg)
+ tolfenamic acid (200 mg)
rizatriptan (10 mg)
+ rofecoxib (50 mg)
rizatriptan (10 mg)
single dose
(2 attacks treated)
Krymchantowski et al. 2006 [31] double-blind, randomized, cross-over study rizatriptan (10 mg)
+ trimebutine (200 mg)
rizatriptan (10 mg)
single dose
(2 attacks treated)
Freitag et al. 2008 [32] randomized, double-blind, placebo-controlled study rizatriptan (10 mg)
+ acetaminophen (1000 mg)
rizatriptan (10 mg)
acetaminophen (1000 mg)
placebo
single dose
Schoenen et al. 2008 [33] multicenter, double-blind, double-dummy, cross-over pilot study almotriptan (12.5 mg)
+ aceclofenac (100 mg)
almotriptan (12.5 mg)
+ placebo
single dose