From: Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease
Preferred term | Donepezil 23 mg/d (n = 963) | Donepezil 10 mg/d (n = 471) |
---|---|---|
Percentage of patients with at least 1 AE | 73.7 | 63.7 |
Nausea | 11.8 | 3.4 |
Vomiting | 9.2 | 2.5 |
Diarrhea | 8.3 | 5.3 |
Anorexia | 5.3 | 1.7 |
Dizziness | 4.9 | 3.4 |
Weight decreased | 4.7 | 2.5 |
Urinary tract infection | 4.4 | 4.0 |
Headache | 4.3 | 3.2 |
Fall | 4.0 | 3.8 |
Agitation | 3.9 | 3.8 |
Insomnia | 3.4 | 2.3 |
Bradycardia | 2.7 | 0.6 |
   Sinus bradycardia | 1.1 | 0.0 |
Aggression | 2.7 | 2.5 |
Urinary incontinence | 2.5 | 1.3 |
Fatigue | 2.4 | 0.8 |
Asthenia | 2.1 | 0.6 |
Contusion | 2.1 | 0.2 |
Somnolence | 2.1 | 1.1 |