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Table 5 Meta-analysis summary odds ratios (95% CI) for the association of the T allele homozygosity with migraine

From: Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis

 

All migraine

MA only

MO only

 

(15 studies)

(15 studies)

(4 studies)

 

N = 4,365 cases

N = 3,862 cases

N = 503 cases

 

N = 30,110 controls

N = 30,110 controls

N = 674 controls

All studies

1.37 (1.07-1.76) "a"

1.42 (1.10-1.82) "a"

1.16 (0.36-3.76)

Excluding 1 study of women only "b"

1.46 (1.11-1.92) "a"

1.54 (1.17-2.02) "a"

1.16 (0.36-3.76)

Ethnic ancestry

   

   European

1.20 (0.95-1.53)

1.28 (1.002-1.63) "a"

0.73 (0.24-2.24)

   Non-European

3.46 (1.22-9.82) "a"

2.81 (0.84-9.44)

------- "c"

  1. "a" Statistically significant.
  2. "b" All studies included men and women except for Schurks et al 2008 which enrolled only women.
  3. "c" No summary OR was computed, since there was only 1 study.