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Table 7 Change over time for CDR domain scores, CDR composite, DSST, MSFC components and MSFC

From: Cognitive performance in relapsing remitting multiple sclerosis: A longitudinal study in daily practice using a brief computerized cognitive battery

 

Main Effect of Time-point

Power of Attention

F 0.39 [8,300] p = 0.928

Continuity of Attention

F 0.68 [8,300] p = 0.708

Quality of Working Memory

F 5.6 [8,300] p < 0.0001

Quality of Episodic Memory

F 0.64 [8,300] p = 0.7458

Speed of Memory

F 0.67 [8,300] p = 0.7157

CDR composite

F 1.42 [8,274] p = 0.1876

DSST

F 1.48 [8,300] p = 0.1627

Timed 25-FWT

F 1.15 [7,267] p = 0.33

9-HPT

F 0.51 [7,265] p = 0.8238

PASAT 3"

F 6.96 [7,266] p < 0.0001

MSFC

F 1.68 [7,264] p = 0.1152

  1. F, F ratio (PROC Mixed analysis of covariance output); CDR, Cognitive Drug Research, DSST, Digit Symbol Substitution Test; MSFC, Multiple Sclerosis Functional Composite; Timed 25-FWT, Timed 25 Foot Walk Test; 9-HPT, 9 Hole Peg Test, PASAT 3", Paced Auditory Serial Addition Test 3 sec. Correcting for multiplicity p-values are statistically significant at p < 0.005.