Figure 1From: Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3expression and decreasing spinal microglial activation Intrathecal lidocaine pretreatment attenuated neurobehavioral responses to thermal and mechanical stimuli. (A) Mechanical responses. Comparison of mean paw withdrawal in response to a mechanical stimulus (F = 50 g; T = 20 seconds) between ipsilateral (left) and contralateral (right) sides in each group. Differences in mean paw withdrawal thresholds between hindpaws were significantly higher in Group L than in Group P on POD3 (**P <0.01). (B) Hyperalgesic responses. On POD3, the difference in mean withdrawal threshold between left and right hindpaws was significantly larger (☆P <0.001) in Group L than in Group P. Mean withdrawal thresholds did not significantly differ between left and right hindpaws in Group S. Data represent means ± SE.Back to article page