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Table 4 Relationship of total number of "at-risk" genotypes of polymorphisms involved in dopaminergic neurotransmission to Parkinson's disease

From: Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population

Number of "at-risk"*

alleles

Subjects, n (%)

Adjusted† OR (95% CI)

 

Cases

(n = 238)

Controls**

(n = 368)

   

0

0 (0.0)

0 (0.0)

-

-

-

1

2 (0.84)

6 (1.63)

1.0 (reference)

1.0

 

2

8 (3.36)

16 (4.35)

1.41 (0.22 - 9.06)

(reference)

1.0 (reference)

3

25 (10.5)

46 (12.5)

1.59 (0.29 - 8.74)

1.23 (0.49 - 3.09)

 

4

51 (21.4)

100 (27.2)

1.65 (0.31 - 8.78)

1.28 (0.54 - 2.99)

1.10 (0.64 - 1.90)

5

73 (30.7)

107 (29.1)

2.13 (0.41 - 11.2)

1.64 (0.71 - 3.79)

1.42 (0.85 - 2.39)

6

51 (21.4)

65 (17.7)

2.39 (0.45 - 12.7)

1.84 (0.78 - 4.36)

 

7

25 (10.5)

26 (7.07)

3.47 (0.62 - 19.4)

2.66

1.80 (1.07 - 3.05)

8

3 (1.26)

2 (0.54)

3.25 (0.28 - 37.8)

(1.03 - 6.88)

 
   

P trend = 0.007

P trend = 0.007

P trend = 0.012

  1. * Based on our results, we designated the allele that is presumed to increase the risk of PD as the "at-risk" allele.
  2. **One control was missing.
  3. †Adjusted for age, sex, first degree family history of PD, region, smoking status, drinking status and pesticide exposure.
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BMC Neurology

ISSN: 1471-2377

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