Skip to main content

Table 1 Glycine sensitivity at the WT and mutated glycine receptors

From: 4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors

glycine

EC50[mM] ± SEM

nH± SEM

N=

Mean current amplitude [pA] ± SEM

Rise time [ms] ± SEM

Current amplitude [% of mean WT current amplitude] ± SEM

WT

0.04±0.02

0.8±0.7

7

1645±426

3.7±0.8

100.0±26

R271Q

26.3±17.7

1.0±0.6

6

123±19

673±224

7.5±15

R271L

102.1±15.0

1.8±0.7

5

336±51

998±129

20.5±12

R271K

0.43±0.29

1.0±0.5

6

526±97

14.9±7.7

32.0±18

S267I

0.12±0.05

1.1±0.2

4

1122±765

6.6±2.5

68.2±68

  1. EC50 values, corresponding Hill coefficients (nH) as well as rise time values and mean maximal current amplitudes are depicted for glycine receptor activation by the natural agonist glycine.