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Table 1 Glycine sensitivity at the WT and mutated glycine receptors

From: 4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors

glycine EC50[mM] ± SEM nH± SEM N= Mean current amplitude [pA] ± SEM Rise time [ms] ± SEM Current amplitude [% of mean WT current amplitude] ± SEM
WT 0.04±0.02 0.8±0.7 7 1645±426 3.7±0.8 100.0±26
R271Q 26.3±17.7 1.0±0.6 6 123±19 673±224 7.5±15
R271L 102.1±15.0 1.8±0.7 5 336±51 998±129 20.5±12
R271K 0.43±0.29 1.0±0.5 6 526±97 14.9±7.7 32.0±18
S267I 0.12±0.05 1.1±0.2 4 1122±765 6.6±2.5 68.2±68
  1. EC50 values, corresponding Hill coefficients (nH) as well as rise time values and mean maximal current amplitudes are depicted for glycine receptor activation by the natural agonist glycine.