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Table 1 Underlying diseases of patients positive and negative for JCV DNA on the basis of CSF specimens

From: Characteristics of progressive multifocal leukoencephalopathy clarified through internet-assisted laboratory surveillance in Japan

Underlying disease

No. (%) of JCV-positive patients

No. (%) of JCV-negative patients

Category

Subcategory

  

HIV infection / AIDS

 

16

(20.3)

63

(79.7)

Hematologic disorders

 

19

(23.5)

62

(76.5)

 

Acute myeloid leukemia

2

(16.7)

10

(83.3)

 

Acute lymphocytic leukemia

1

(14.3)

6

(85.7)

 

Chronic myeloid leukemia

0

(0)

2

(100)

 

Chronic lymphocytic leukemia

1

(50.0)

1

(50.0)

 

Adult T-cell leukemia

1

(50.0)

1

(50.0)

 

Hodgkin's lymphoma

1

(50.0)

1

(50.0)

 

Non-Hodgkin's lymphoma

6

(22.2)

21

(77.8)

 

Aplastic anemia

2

(50.0)

2

(50.0)

 

Primary immunodeficiency syndrome

2

(25.0)

6

(75.0)

 

Multiple myeloma

2

(66.7)

1

(33.3)

 

Primary macroglobulinemia

1

(100)

0

(0)

 

Myelodysplastic syndrome

0

(0)

6

(100)

 

Other

0

(0)

5

(100)

Autoimmune disorders

 

3

(6.0)

47

(94.0)

 

Multiple sclerosis

0

(0)

11

(100)

 

Rheumatoid arthritis

0

(0)

7

(100)

 

Systemic lupus erythematosus

3

(20.0)

12

(80.0)

 

Other

0

(0)

17

(100)

Other diseases

 

9

(10.0)

81

(90.0)

 

Cerebrovascular disorders

0

(0)

7

(100)

 

Solid-organ cancer

0

(0)

13 a

(100)

 

Lung diseases

2

(66.7)

1

(33.3)

 

HCV-related liver disease

3

(37.5)

5

(62.5)

 

Renal diseases

0

(0)

11 b

(100)

 

Sarcoidosis

3

(100)

0

(0)

 

Other

1 c

(2.2)

44 d

(97.8)

None/Unknown

 

1

(0.8)

118

(99.2)

Total

 

48

(11.5)

371

(88.5)

  1. HCV, hepatitis C virus.
  2. a Two patients underwent liver transplantation.
  3. b Six patients underwent renal transplantation.
  4. c The patient receiving the liver transplant had common variable immunodeficiency.
  5. d One patient received heart and kidney transplants.