Reference | Q1. Was the WML identification done by a radiologist/physician? | Q2. Was the cognitive performance measured using a standardized method? | Q3. Was there a sample size calculation? | Q4. Were age or education considered as confounders? |
---|---|---|---|---|
Groot et al. et al. [24] | + | + | - | + |
Shenkin et al. [25] | + | + | - | - |
Baune et al. [26] | - | + | - | + |
Kim et al. [27] | - | + | - | + |
Silbert et al. [28] | - | + | - | + |
McClleland et al. [21] | + | + | - | + |
Wright et al. [29] | - | + | - | + |
Kaplan et al. [30] | - | + | - | + |
Wakefield et al. [31] | - | + | - | + |
O’Brien et al. [32] | + | + | - | + |
Smith et al. [14] | - | + | - | + |
Burns et al. [33] | + | + | - | + |
Ishii et al. [34] | + | + | - | + |
Tullberg et al. [35] | - | + | - | - |