Table 1 Clinical data of the whole cohort as well as clinical and molecular-genetic subtypes
From: Retinal nerve fibre layer loss in hereditary spastic paraplegias is restricted to complex phenotypes
Age [years] | Disease duration [years] | SPRS [scoring points] | Phenotype | |
|---|---|---|---|---|
HSP-a (n=28) | 48.1 (8–75) | 19.1 (4–40) | 20.8 (3–30) | complex & pure, see subgroups |
HSP-p (n=22) | 49.5 (8–75) | 21.8 (5–43) | 21.5 (3–31) | spastic paraparesis, pure phenotype |
HSP-c (n=6) | 42.8 (22–60) | 9.5 (4–18) | 18 (8–31) | most frequent complicating symptoms: gaze-evoked-nystagmus or ataxia |
SPG4 (n=13) | 46.1 (8–74) | 21.5 (7–37) | 20.8 (3–30) | spastic paraparesis, pure phenotype |
SPG5 (n=1) | 48 | 43 | 23 | pure phenotype |
SPG7 (n=3) | 38.3 (28–48) | 9.7 (4–14) | 17.7 (8–31) | one pure, two complex phenotypes (see text) |