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Table 1 Biomarkers and neuropsychiatric performances between patients with temporal lobe

From: Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy

 

Controls (n = 34)

TLE patients (n = 34)

Biomarkers

  

   Heat shock protein 70 (μg/ml)

130.84 ± 61.1

194.5 ± 116.1**

   Non-specific enolase (ng/ml)

9.43 ± 1.9

9.51 ± 1.9

   S100ß protein (pg/ml)

70.52 ± 28.0

99.83 ± 45.7 **

   Plasma nuclear DNA (ng/ml)

28.62 ± 2.5

29.19 ± 2.7

   Plasma mitochondrial DNA (ng/ml)

21.33 ± 1.1

21.15 ± 1.0

Verbal Memory CVLT-MS (9)

  

   T1

6.18 ± 1.1

5.18 ± 1.5**

   T2

7.74 ± 1.1

7.36 ± 1.4

   T3

8.24 ± 0.9

8.06 ± 1.2

   T4

8.59 ± 0.7

8.15 ± 1.0

   30 sec free recall

8.65 ± 0.7

7.67 ± 2.0**

   10-min free recall

8.38 ± 1.2

7.18 ± 2.3**

   10-min recognition

8.53 ± 0.9

7.55 ± 1.8

Visual Memory

  

   Modified Rey-Osterrieth recall (17)

15 ± 2.5

11.64 ± 4.5**

Visuospatial Functions

  

   Modified Rey-Osterrieth copy (17)

17 ± 0

16.79 ± 0.7

   Cube copy (2)

1.82 ± 0.5

1.05 ± 0.9

   Pentagon copy (1)

1 ± 0

0.82 ± 0.4

   Visual object and space perception (10)

8.29 ± 2.0

8.64 ± 1.8

Speech and Language Ability

  

   Semantic Fluency (1 minute)

  

Animal

21.59 ± 3.9

15.3 ± 5.4**

Fruit

15.75 ± 2.8

11.54 ± 3.4**

Transportation

13.83 ± 3.8

9.26 ± 2.1**

Town

24.28 ± 6.2

16.82 ± 6.2**

   Boston naming test (16)

15.58 ± 0.8

14.36 ± 2.2**

   Comprehension (4)

3.88 ± 0.3

3.51 ± 0.9

Abstract thinking (3)

2.58 ± 0.7

1.97 ± 1.2

Problem solving (3)

2.60 ± 0.7

2.00 ± 1.1

Executive function

  

   Digit backward

5.0 ± 1.6

4.74 ±1.5

   Stroop interference correct (1 minute)

54.1 ± 10.9

40.33 ± 14.6**

   Design fluency

10.78 ± 3.0

8.56 ± 5.6*

   Trail Making test time (< 120 seconds)

23.6 ± 11.6

47.8 ± 35.3**

   Correct line in Trail Making (14)

13.13 ± 2.7

11.92 ± 3.5

Calculation (5)

4.75 ± 0.7

4.51 ± 0.8

Digit forward

8.40 ± 0.8

7.44 ± 1.4**

Neuropsychiatric inventory score

1.91 ± 6.6

2.84 ± 5.5

  1. Values expressed as mean ± standard deviation.
  2. Number in parenthesis following task name = maximal scores
  3. **p < 0.01. *p < 0.05 between TLE patients and controls
  4. TLE temporal lobe epilepsy; CVLT-MS California Verbal Learning Test-Mental Status
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BMC Neurology

ISSN: 1471-2377

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