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Table 1 Biomarkers and neuropsychiatric performances between patients with temporal lobe

From: Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy

  Controls (n = 34) TLE patients (n = 34)
Biomarkers   
   Heat shock protein 70 (μg/ml) 130.84 ± 61.1 194.5 ± 116.1**
   Non-specific enolase (ng/ml) 9.43 ± 1.9 9.51 ± 1.9
   S100ß protein (pg/ml) 70.52 ± 28.0 99.83 ± 45.7 **
   Plasma nuclear DNA (ng/ml) 28.62 ± 2.5 29.19 ± 2.7
   Plasma mitochondrial DNA (ng/ml) 21.33 ± 1.1 21.15 ± 1.0
Verbal Memory CVLT-MS (9)   
   T1 6.18 ± 1.1 5.18 ± 1.5**
   T2 7.74 ± 1.1 7.36 ± 1.4
   T3 8.24 ± 0.9 8.06 ± 1.2
   T4 8.59 ± 0.7 8.15 ± 1.0
   30 sec free recall 8.65 ± 0.7 7.67 ± 2.0**
   10-min free recall 8.38 ± 1.2 7.18 ± 2.3**
   10-min recognition 8.53 ± 0.9 7.55 ± 1.8
Visual Memory   
   Modified Rey-Osterrieth recall (17) 15 ± 2.5 11.64 ± 4.5**
Visuospatial Functions   
   Modified Rey-Osterrieth copy (17) 17 ± 0 16.79 ± 0.7
   Cube copy (2) 1.82 ± 0.5 1.05 ± 0.9
   Pentagon copy (1) 1 ± 0 0.82 ± 0.4
   Visual object and space perception (10) 8.29 ± 2.0 8.64 ± 1.8
Speech and Language Ability   
   Semantic Fluency (1 minute)   
Animal 21.59 ± 3.9 15.3 ± 5.4**
Fruit 15.75 ± 2.8 11.54 ± 3.4**
Transportation 13.83 ± 3.8 9.26 ± 2.1**
Town 24.28 ± 6.2 16.82 ± 6.2**
   Boston naming test (16) 15.58 ± 0.8 14.36 ± 2.2**
   Comprehension (4) 3.88 ± 0.3 3.51 ± 0.9
Abstract thinking (3) 2.58 ± 0.7 1.97 ± 1.2
Problem solving (3) 2.60 ± 0.7 2.00 ± 1.1
Executive function   
   Digit backward 5.0 ± 1.6 4.74 ±1.5
   Stroop interference correct (1 minute) 54.1 ± 10.9 40.33 ± 14.6**
   Design fluency 10.78 ± 3.0 8.56 ± 5.6*
   Trail Making test time (< 120 seconds) 23.6 ± 11.6 47.8 ± 35.3**
   Correct line in Trail Making (14) 13.13 ± 2.7 11.92 ± 3.5
Calculation (5) 4.75 ± 0.7 4.51 ± 0.8
Digit forward 8.40 ± 0.8 7.44 ± 1.4**
Neuropsychiatric inventory score 1.91 ± 6.6 2.84 ± 5.5
  1. Values expressed as mean ± standard deviation.
  2. Number in parenthesis following task name = maximal scores
  3. **p < 0.01. *p < 0.05 between TLE patients and controls
  4. TLE temporal lobe epilepsy; CVLT-MS California Verbal Learning Test-Mental Status