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Table 2 Drug selection strategy for PD patients under specific circumstances among doctors at different levels

From: Current clinical practice for Parkinson’s disease among Chinese physicians, general neurologists and movement disorders specialists: a national survey

Items

Total (n=489)

Physicians (n=67)

General neurologists (n=344)

Movement disorders specialists (n=78)

P value

Age < 65 years without cognitive impairment

Levodopa

164(33.5%)

28(41.8%)

114(33.1%)

22(28.2%)

0.216

Dopamine agonists

210(42.9%)

13(19.4%)

144(41.9%)

53(67.9%)

0.000

MAO-B inhibitors

62(12.7%)

8(11.9%)

37(10.8%)

17(21.8%)

0.030

Age > 65 years or with cognitive impairment

Levodopa

277(56.6%)

30(44.8%)

192(55.8%)

55(70.5%)

0.007

Dopamine agonists

114(23.3%)

8(11.9%)

80(23.3%)

26(33.3%)

0.01

MAO-B inhibitors

41(8.4%)

7(10.4%)

26(7.6%)

8(10.3%)

0.597

Wearing-off phenomenon

     

Add levodopa frequency

187(38.2%)

14(20.9%)

131(38.1%)

42(53.8%)

0.000

Switch to CR levodopa

236(48.3%)

15(22.4%)

173(50.3%)

48(61.5%)

0.000

Add COMT inhibitors or MAO-B inhibitors

203(41.5%)

21(31.3%)

136(39.5%)

46(59.0%)

0.001

Add dopamine agonists

196(40.1%)

15(22.4%)

143(41.6%)

38(48.7%)

0.003

Peak-dose dyskinesia

     

Reduce levodopa dose, add its frequency

218(44.6%)

24(35.8%)

149(43.3%)

45(57.7%)

0.021

Reduce levodopa dose, add dopamine agonists

215(44.0%)

15(22.4%)

151(43.9%)

49(62.8%)

0.000

Reduce levodopa dose, add COMT inhibitors

145(29.7%)

15(22.4%)

97(28.2%)

33(42.3%)

0.018

Add amantadine

71(14.5%)

8(11.9%)

38(11.0%)

25(32.1%)

0.000

PD with psychosis

     

Clozapine

112(22.9%)

11(16.4%)

67(19.5%)

34(43.6%)

0.000

Olanzapine

224(45.8%)

27(40.3%)

162(47.1%)

35(44.9%)

0.584

Quetiapine

106(21.7%)

9(13.4%)

68(19.8%)

29(37.2%)

0.001

PD with dementia

     

Huperzine A

124(25.4%)

8(11.9%)

101(29.3%)

15(19.2%)

0.004

Donepezil

263(53.8%)

30(44.8%)

178(51.7%)

55(70.5%)

0.003

Rivastigmine

82(16.8%)

10(14.9%)

50(14.5%)

22(28.2%)

0.013

Memantine

185(37.8%)

15(22.4%)

126(36.6%)

44(56.4%)

0.000

PD with depression

     

Tricyclic antidepressants

101(20.7%)

13(19.4%)

79(23.0%)

9(11.5%)

0.077

SSRIs

292(59.7%)

31(46.3%)

200(58.1%)

61(78.2%)

0.000

Pramipexole

185(37.8%)

16(23.9%)

125(36.3%)

44(56.4%)

0.000

PD with RLS

     

Levodopa

123(25.2%)

11(16.4%)

86(25.0%)

26(33.3%)

0.064

Dopamine agonists

149(30.5%)

15(22.4%)

90(26.2%)

44(56.4%)

0.000

Benzodiazepines

140(28.6%)

15(22.4%)

108(31.4%)

17(21.8%)

0.114