Example of typical macrostructural WM alterations on conventional structural MRI (A) and the correspondent FA changes (B). A: T2w image of one patient showing mainly unilateral hyperintense macrostructural lesions. B: Computer reconstructed hyperintensities of the same T2w dataset (red) overlaid with the patients FA (blue). Only FA values > 0.2 are shown. Close to the lesion (yellow circle) the FA is reduced (FA < 0.2) in comparison to the contralateral side. Similarly, uni- or bilaterally highly significant FA reductions were found in patients with macrostrucural lesions, as well as in patients without macrostructural WM hyperintensities.