Locomotor activity recorded using actimetry. (A) Actogram records graphed as a double plot showing the locomotor activity of case 1. The actograms show the activity for the period between episodes and that of symptomatic periods. (B) Statistical analysis of locomotor activity. Based on bed time of the period between episodes, daily activity (0:00–24:00) was divided into sleep (0:00–7:00) and active (7:00–24:00) times. Data are represented as the mean ± SEM. Asterisks indicate statistically significant differences as determined by a Student’s t-test (p < 0.0005).