Table 2 Summary estimates of diagnostic accuracy from autopsy studies, according to imaging finding and method
Imaging finding | Number of studies | Sample size | Sensitivity (95% CI) | tau2 for sensitivity | Specificity (95% CI) | tau2 for specificity | Positive likelihood ratio (95% CI) | Negative likelihood ratio (95% CI) | DOR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
CT | |||||||||
White matter hyperintensities | 2 | 84 | 73 (58, 84) | 0 | 63 (46, 77) | 0 | 1.96 (1.23, 3.12) | 0.43 (0.25, 0.75) | 4.5 (1.70, 12) |
Global assessment | 1 | 32 | 18 (6, 41) | — | 80 (55, 93) | — | 0.88 (0.21, 3.73) | 1.03 (0.74, 1.44) | 0.9 (0.20, 4.50) |
Periventricular hyperintensities | 3 | 31 | 85 (43, 98) | 1.95 | 50 (11, 89) | 2.12 | 1.70 (0.58, 5.05) | 0.30 (0.04, 2.18) | 5.6 (0.32, 100) |
Lacunar infarcts | 1 | 96 | 12 (4, 29) | — | 100 (57, 100) | — | 1.40 (0.08, 23.74) | 0.96 (0.73, 1.27) | ∞ (0.14, ∞) |
Non-lacunar infarcts | 2 | 79 | 70 (56, 81) | 0 | 93 (80, 99) | 0 | 12.75 (3.28, 49.60) | 0.31 (0.20,0.48) | 41 (8.20, 196) |
General infarcts | 2 | 123 | 41 (5, 89) | 2.8 | 78 (32, 96) | 1.7 | 1.82 (0.22,15.20) | 0.76 (0.25,2.30) | 2.4 (0.10, 57) |
MRI | |||||||||
White matter hyperintensities | 1 | 43 | 79 (52, 92) | — | 28 (15, 46) | — | 1.09 (0.76, 1.55) | 0.78 (0.24, 2.49) | 1.4 (0.33, 5.80) |