| Follow-up interval (years) | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | <1 | 1-5 | 5-10 | > = 10 | All | |||||||||||||||
Immune-mediated diseases | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||||
Addison´s disease | 14 | 2.71 | 1.48 | 4.56 | 28 | 1.17 | 0.78 | 1.69 | 30 | 1.90 | 1.28 | 2.72 | 11 | 0.97 | 0.48 | 1.74 | 83 | 1.48 | 1.18 | 1.83 |
Amyotrophic lateral sclerosis | 7 | 0.53 | 0.21 | 1.10 | 16 | 1.52 | 0.87 | 2.47 | 7 | 1.77 | 0.70 | 3.67 | 2 | 1.15 | 0.11 | 4.23 | 32 | 1.09 | 0.74 | 1.54 |
Ankylosing spondylitis | 8 | 1.62 | 0.69 | 3.21 | 44 | 1.55 | 1.13 | 2.08 | 24 | 0.98 | 0.63 | 1.46 | 35 | 1.08 | 0.75 | 1.50 | 111 | 1.23 | 1.01 | 1.48 |
Autoimmune hemolytic anemia | 4 | 1.45 | 0.38 | 3.75 | 12 | 1.00 | 0.51 | 1.75 | 19 | 2.51 | 1.51 | 3.93 | 5 | 1.23 | 0.39 | 2.90 | 40 | 1.51 | 1.08 | 2.06 |
Behcet´s disease | 1 | 4.00 | 0.00 | 22.93 | 1 | 0.65 | 0.00 | 3.70 | 0 |  |  |  | 1 | 1.43 | 0.00 | 8.19 | 3 | 0.78 | 0.15 | 2.29 |
Celiac disease | 9 | 2.17 | 0.99 | 4.14 | 29 | 1.28 | 0.86 | 1.84 | 21 | 1.17 | 0.72 | 1.78 | 26 | 1.47 | 0.96 | 2.15 | 85 | 1.36 | 1.09 | 1.68 |
Chorea minor | 0 | Â | Â | Â | 1 | 2.27 | 0.00 | 13.03 | 0 | Â | Â | Â | 0 | Â | Â | Â | 1 | 1.11 | 0.00 | 6.37 |
Crohn disease | 49 | 2.15 | 1.59 | 2.84 | 160 | 1.33 | 1.13 | 1.55 | 103 | 1.11 | 0.91 | 1.35 | 97 | 1.15 | 0.93 | 1.40 | 409 | 1.28 | 1.16 | 1.41 |
Diabetes mellitus type I | 1 | 6.25 | 0.00 | 35.83 | 2 | 0.45 | 0.04 | 1.65 | 5 | 2.75 | 0.87 | 6.46 | 17 | 5.00 | 2.91 | 8.02 | 25 | 2.54 | 1.64 | 3.76 |
Discoid lupus erythematosus | 3 | 4.23 | 0.80 | 12.51 | 3 | 0.99 | 0.19 | 2.92 | 1 | 0.47 | 0.00 | 2.70 | 3 | 1.55 | 0.29 | 4.60 | 10 | 1.28 | 0.61 | 2.37 |
Grave´s disease | 101 | 2.15 | 1.76 | 2.62 | 402 | 1.39 | 1.26 | 1.53 | 348 | 1.36 | 1.22 | 1.51 | 276 | 1.27 | 1.12 | 1.43 | 1127 | 1.39 | 1.31 | 1.48 |
Hashimoto´s thyroiditis | 77 | 2.99 | 2.36 | 3.74 | 211 | 1.73 | 1.50 | 1.98 | 115 | 1.39 | 1.14 | 1.67 | 82 | 1.28 | 1.02 | 1.59 | 485 | 1.64 | 1.50 | 1.80 |
Immune thrombocytopenic purpura | 16 | 2.35 | 1.34 | 3.83 | 55 | 1.77 | 1.33 | 2.30 | 19 | 0.94 | 0.57 | 1.48 | 14 | 1.20 | 0.65 | 2.01 | 104 | 1.49 | 1.22 | 1.81 |
Localized scleroderma | 2 | 1.28 | 0.12 | 4.71 | 13 | 1.25 | 0.66 | 2.14 | 18 | 1.72 | 1.01 | 2.72 | 11 | 1.04 | 0.51 | 1.86 | 44 | 1.33 | 0.97 | 1.79 |
Lupoid hepatitis | 3 | 4.48 | 0.84 | 13.25 | 4 | 1.98 | 0.52 | 5.12 | 0 | Â | Â | Â | 0 | Â | Â | Â | 7 | 2.10 | 0.83 | 4.36 |
Multiple sclerosis | 40 | 3.05 | 2.18 | 4.15 | 73 | 1.09 | 0.85 | 1.37 | 55 | 1.11 | 0.83 | 1.44 | 35 | 0.95 | 0.66 | 1.32 | 203 | 1.22 | 1.06 | 1.40 |
Myasthenia gravis | 6 | 1.01 | 0.36 | 2.21 | 38 | 1.36 | 0.96 | 1.87 | 23 | 1.20 | 0.76 | 1.80 | 13 | 1.08 | 0.57 | 1.85 | 80 | 1.23 | 0.97 | 1.53 |
Pernicious anemia | 25 | 1.56 | 1.01 | 2.31 | 138 | 1.49 | 1.25 | 1.76 | 89 | 1.23 | 0.99 | 1.52 | 74 | 1.44 | 1.13 | 1.80 | 326 | 1.40 | 1.25 | 1.56 |
Polyarteritis nodosa | 5 | 1.23 | 0.39 | 2.89 | 20 | 1.30 | 0.79 | 2.02 | 11 | 1.05 | 0.52 | 1.88 | 10 | 1.13 | 0.54 | 2.08 | 46 | 1.19 | 0.87 | 1.58 |
Polymyalgia rheumatica | 165 | 1.76 | 1.50 | 2.05 | 761 | 1.50 | 1.39 | 1.61 | 529 | 1.54 | 1.41 | 1.68 | 322 | 1.53 | 1.37 | 1.71 | 1777 | 1.54 | 1.47 | 1.61 |
Polymyositis/ dermatomyositis | 10 | 3.46 | 1.65 | 6.39 | 13 | 1.19 | 0.63 | 2.03 | 6 | 1.07 | 0.38 | 2.34 | 5 | 1.73 | 0.55 | 4.07 | 34 | 1.52 | 1.05 | 2.13 |
Primary biliary cirrhosis | 4 | 1.54 | 0.40 | 3.98 | 11 | 1.45 | 0.72 | 2.60 | 4 | 0.91 | 0.24 | 2.35 | 1 | 2.17 | 0.00 | 12.46 | 20 | 1.33 | 0.81 | 2.05 |
Psoriasis | 44 | 1.92 | 1.39 | 2.58 | 217 | 1.65 | 1.44 | 1.89 | 163 | 1.53 | 1.30 | 1.78 | 144 | 1.41 | 1.19 | 1.66 | 568 | 1.56 | 1.44 | 1.70 |
Reiter´s disease | 0 |  |  |  | 5 | 2.02 | 0.64 | 4.76 | 6 | 2.47 | 0.89 | 5.41 | 2 | 0.56 | 0.05 | 2.07 | 13 | 1.47 | 0.78 | 2.52 |
Rheumatic fever | 5 | 3.91 | 1.23 | 9.19 | 10 | 1.66 | 0.79 | 3.06 | 14 | 3.04 | 1.65 | 5.11 | 7 | 1.81 | 0.72 | 3.75 | 36 | 2.28 | 1.59 | 3.16 |
Rheumatoid arthritis | 345 | 2.08 | 1.86 | 2.31 | 1266 | 1.66 | 1.57 | 1.75 | 663 | 1.45 | 1.34 | 1.56 | 326 | 1.30 | 1.16 | 1.45 | 2600 | 1.59 | 1.53 | 1.65 |
Sarcoidosis | 9 | 0.97 | 0.44 | 1.85 | 70 | 1.43 | 1.12 | 1.81 | 51 | 1.12 | 0.83 | 1.47 | 56 | 1.08 | 0.81 | 1.40 | 186 | 1.19 | 1.03 | 1.38 |
Sjögren´s syndrome | 10 | 2.57 | 1.22 | 4.75 | 28 | 1.38 | 0.92 | 1.99 | 15 | 0.96 | 0.54 | 1.59 | 15 | 1.26 | 0.70 | 2.08 | 68 | 1.31 | 1.02 | 1.67 |
Systemic lupus erythematosus | 19 | 2.21 | 1.33 | 3.46 | 88 | 2.33 | 1.87 | 2.87 | 54 | 1.92 | 1.44 | 2.51 | 30 | 1.26 | 0.85 | 1.80 | 191 | 1.94 | 1.68 | 2.24 |
Systemic sclerosis | 11 | 1.90 | 0.94 | 3.41 | 28 | 1.22 | 0.81 | 1.77 | 11 | 1.19 | 0.59 | 2.14 | 2 | 0.39 | 0.04 | 1.43 | 52 | 1.21 | 0.90 | 1.58 |
Ulcerative colitis | 71 | 2.15 | 1.68 | 2.71 | 231 | 1.27 | 1.11 | 1.45 | 162 | 1.09 | 0.92 | 1.27 | 146 | 1.05 | 0.89 | 1.24 | 610 | 1.21 | 1.12 | 1.31 |
Wegener´s granulomatosis | 11 | 1.66 | 0.82 | 2.98 | 12 | 0.47 | 0.24 | 0.83 | 26 | 1.54 | 1.00 | 2.25 | 12 | 1.69 | 0.87 | 2.96 | 61 | 1.09 | 0.83 | 1.40 |
All | 1075 | 2.02 | 1.90 | 2.14 | 3990 | 1.50 | 1.46 | 1.55 | 2592 | 1.38 | 1.33 | 1.43 | 1780 | 1.29 | 1.23 | 1.35 | 9437 | 1.46 | 1.43 | 1.49 |