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Figure 4 | BMC Neurology

Figure 4

From: Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

Figure 4

Immunofluorescence staining (A) and quantification of the expression of OX-42 (B) in microglia of the spinal dorsal horn (SDH). SNL (group L) induced a dramatic increase in OX-42 positive microglia in the SDH. Both amitriptyline regimens (group A and P) reduced the expression of OX-42 immunoreactivity in microglia for 2 weeks (B). Group P showed a greater effect than group A on reduction of activated microglia in SDH on POD4. Scale bars = 200 μm. Data represent mean ± SE, the Mann–Whitney U test was used for statistical comparison. (n = 24/group, 4-5/each time point). *p < 0.05; **p < 0.01, NS: not significant. POD: postoperative day; S: Sham; L: Ligation; A: post-injury intra-peritoneal amitriptyline; P: Pretreatment with intrathecal amitriptyline in addition to post-injury intra-peritoneal amitriptyline.

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BMC Neurology

ISSN: 1471-2377

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