Association with major KEGG pathways. A) KEGG signaling pathways with more than 15 HD-relevant genes and an odds ratio ≥ 2.0 are included on the pie-chart. Numbers refer to HD-relevant genes in a pathway. Highly significantly enriched pathways (FDR ≤ 0.01) are highlighted by bold font. Pathways with odds ratio ≥ 3.0 are set in red font. B) Odd ratios are displayed for enrichment of selected pathways.