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Table 2 Candidate list of genetic modifiers

From: Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database

 

Entrez ID

Symbol

TVS

Chr.

Band

Region = 2q33-2q35

7341

SUMO1

3

2

q33.1

 

9689

BZW1

3

2

q33.1

 

23451

SF3B1

3

2

q33.1

HD MAPS: LOD =1.63 (at 2q33)

1385

CREB1

3.5

2

q33.3

Gayan et al: LOD =3.39 (at 2q35)

7855

FZD5

3

2

q33.3

 

3300

DNAJB2

3

2

q35

 

8941

CDK5R2

3

2

q35

 

10109

ARPC2

3

2

q35

Region = 4p16

6286

S100P

3

4

p16.1

 

9948

WDR1

3

4

p16.1

HD MAPS: LOD =1.93

118

ADD1

3

4

p16.3

Gáyan et al : LOD =1.49

3064

HTT

4

4

p16.3

 

7469

WHSC2

3

4

p16.3

Region = 5q31-32

3308

HSPA4

3.5

5

q31.1

 

6500

SKP1

3

5

q31.1

 

2107

ETF1

3

5

q31.2

HD MAPS: LOD = 2.02 (at 5q31-32)

3313

HSPA9

3

5

q31.2

Gáyan et al: LOD =3.14 (at 5q32)

7322

UBE2D2

3

5

q31.2

 

8841

HDAC3

4

5

q31.3

 

10915

TCERG1

3

5

q32

 

133522

PPARGC1B

3

5

q32

Region = 6q22-24

2444

FRK

3

6

q22.1

 

6206

RPS12

3

6

q23.2

HD MAPS: LOD =2.28 (at 6q23-24)

9439

MED23

3

6

q23.2

Gáyan et al: LOD =2.48 (at 6q22)

4217

MAP3K5

4

6

q23.3

 

2911

GRM1

3

6

q24.3

  1. HD-relevant genes located in the four chromosomal regions implicated by both genome-wide scans [24, 25]. The LOD scores reported in these studies for the exact location are shown on the left column.