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Table 2 Candidate list of genetic modifiers

From: Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database

  Entrez ID Symbol TVS Chr. Band
Region = 2q33-2q35 7341 SUMO1 3 2 q33.1
  9689 BZW1 3 2 q33.1
  23451 SF3B1 3 2 q33.1
HD MAPS: LOD =1.63 (at 2q33) 1385 CREB1 3.5 2 q33.3
Gayan et al: LOD =3.39 (at 2q35) 7855 FZD5 3 2 q33.3
  3300 DNAJB2 3 2 q35
  8941 CDK5R2 3 2 q35
  10109 ARPC2 3 2 q35
Region = 4p16 6286 S100P 3 4 p16.1
  9948 WDR1 3 4 p16.1
HD MAPS: LOD =1.93 118 ADD1 3 4 p16.3
Gáyan et al : LOD =1.49 3064 HTT 4 4 p16.3
  7469 WHSC2 3 4 p16.3
Region = 5q31-32 3308 HSPA4 3.5 5 q31.1
  6500 SKP1 3 5 q31.1
  2107 ETF1 3 5 q31.2
HD MAPS: LOD = 2.02 (at 5q31-32) 3313 HSPA9 3 5 q31.2
Gáyan et al: LOD =3.14 (at 5q32) 7322 UBE2D2 3 5 q31.2
  8841 HDAC3 4 5 q31.3
  10915 TCERG1 3 5 q32
  133522 PPARGC1B 3 5 q32
Region = 6q22-24 2444 FRK 3 6 q22.1
  6206 RPS12 3 6 q23.2
HD MAPS: LOD =2.28 (at 6q23-24) 9439 MED23 3 6 q23.2
Gáyan et al: LOD =2.48 (at 6q22) 4217 MAP3K5 4 6 q23.3
  2911 GRM1 3 6 q24.3
  1. HD-relevant genes located in the four chromosomal regions implicated by both genome-wide scans [24, 25]. The LOD scores reported in these studies for the exact location are shown on the left column.