Groups | Time points | p-value1 | p-value2 | |||
---|---|---|---|---|---|---|
Baseline n = 87 | 4 months n = 76 | 8 months n = 74 | 12 months* n = 69 | |||
MMSE ± SD** | ||||||
Stimulation therapy | 22.9 ± 4.5 | 22.2 ± 5.1 | 23.0 ± 4.0 | 22.7 ± 4.8 | 0.040 | 0.0016 |
Donepezil | 23.7 ± 3.7 | 23.8 ± 3.8 | 25.1 ± 3.0 | 23.6 ± 3.8 | ||
Clock Drawing Test ± SD** | ||||||
Stimulation therapy | 2.8 ± 1.3 | 2.9 ± 1.2 | 2.8 ± 1.0 | 2.9 ± 1.1 | 0.940 | 0.713 |
Donepezil | 2.8 ± 1.3 | 2.7 ± 1.3 | 2.8 ± 1.2 | 2.9 ± 1.1 | ||
ADAS-cog ± SD** | ||||||
Stimulation therapy | 18.5 ± 8.7 | 17.9 ± 8.6 | 16.7 ± 8.8 | 17.6 ± 8.6 | 0.225 | 0.060 |
Donepezil | 17.6 ± 5.8 | 15.8 ± 6.9 | 15.1 ± 7.9 | 16.7 ± 8.1 |