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Table 5 Mean cognitive function by follow-up time point and according to a head to head comparison between donepezil versus stimulation therapy

From: The effect of stimulation therapy and donepezil on cognitive function in Alzheimer’s disease. A community based RCT with a two-by-two factorial design

Groups

Time points

p-value1

p-value2

 

Baseline n = 87

4 months n = 76

8 months n = 74

12 months* n = 69

  
 

MMSE ± SD**

  

Stimulation therapy

22.9 ± 4.5

22.2 ± 5.1

23.0 ± 4.0

22.7 ± 4.8

0.040

0.0016

Donepezil

23.7 ± 3.7

23.8 ± 3.8

25.1 ± 3.0

23.6 ± 3.8

  
 

Clock Drawing Test ± SD**

  

Stimulation therapy

2.8 ± 1.3

2.9 ± 1.2

2.8 ± 1.0

2.9 ± 1.1

0.940

0.713

Donepezil

2.8 ± 1.3

2.7 ± 1.3

2.8 ± 1.2

2.9 ± 1.1

  
 

ADAS-cog ± SD**

  

Stimulation therapy

18.5 ± 8.7

17.9 ± 8.6

16.7 ± 8.8

17.6 ± 8.6

0.225

0.060

Donepezil

17.6 ± 5.8

15.8 ± 6.9

15.1 ± 7.9

16.7 ± 8.1

  
  1. n varies due to missing values ** Standard deviation. p-value1 = Equal time trends between groups. p-value2 = Equal time trend between groups adjusted for baseline cognitive function.