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Table 3 Interaction between UCHL1 S18Y and SNCA rs356220 polymorphisms affecting sporadic Parkinson’s disease in a Japanese population

From: UCHL1 S18Y variant is a risk factor for Parkinson’s disease in Japan

 

SNCA rs356220

 

CC + CT

TT

Genotype

No. cases/controls

Adjusted OR (95 % CI)*

No. cases/controls

Adjusted OR (95 % CI)*

CC + CA

92/182

1.00

67/97

1.44 (0.94 − 2.19)

AA

37/48

1.51 (0.91 − 2.53)

33/29

2.31 (1.29 − 4.14)

P for multiplicative interaction = 0.91

  

Measures of additive interaction

  

 Relative excess risk due to interaction (RERI) = 0.34 (95 % CI: -1.14 − 1.81)

 Attributable proportion due to interaction (AP) = 0.15 (95 % CI: -0.44 − 0.73)

 Synergy index (S) = 1.35 (95 % CI: 0.37 − 4.94)

  1. *Adjusted for sex, age, region of residence, smoking, and caffeine intake.
  2. Statistically significant when the 95 % CI of RERI > 0, the 95 % CI of AP > 0, or the 95 % CI of S > 1, indicating additive interaction.