Table 4 Interaction between UCHL1 S18Y polymorphism and smoking status affecting sporadic Parkinson’s disease in a Japanese population
From: UCHL1 S18Y variant is a risk factor for Parkinson’s disease in Japan
Ever smoked | ||||
|---|---|---|---|---|
Yes | No | |||
Genotype | No. cases/controls | Adjusted OR (95 % CI)* | No. cases/controls | Adjusted OR (95 % CI)* |
CC + CA | 42/113 | 1.00 | 117/166 | 2.73 (1.62 − 4.61) |
AA | 20/32 | 1.72 (0.87 − 3.38) | 50/46 | 4.08 (2.18 − 7.63) |
P for multiplicative interaction = 0.74 | ||||
Measures of additive interaction† | ||||
Relative excess risk due to interaction (RERI) = 0.63 (95 % CI: -1.48 − 2.75) | ||||
Attributable proportion due to interaction (AP) = 0.16 (95 % CI: -0.31 − 0.62) | ||||
Synergy index (S) = 1.26 (95 % CI: 0.59 − 2.68) | ||||