From: UCHL1 S18Y variant is a risk factor for Parkinson’s disease in Japan
Caffeine intake | ||||
---|---|---|---|---|
≥ 161.7 mg/4184 kJ | < 161.7 mg/4184 kJ | |||
Genotype | No. cases/controls | Adjusted OR (95 % CI)* | No. cases/controls | Adjusted OR (95 % CI)* |
CC + CA | 58/140 | 1.00 | 101/139 | 1.82 (1.21 − 2.75) |
AA | 28/38 | 1.87 (1.03 − 3.36) | 42/40 | 2.66 (1.55 − 4.59) |
P for multiplicative interaction = 0.55 | ||||
Measures of additive interaction† | ||||
Relative excess risk due to interaction (RERI) = −0.02 (95 % CI: -1.63 − 1.59) | ||||
Attributable proportion due to interaction (AP) = −0.01 (95 % CI: -0.61 − 0.60) | ||||
Synergy index (S) = 0.99 (95 % CI: 0.38 − 2.58) |