From: Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention
Source | Blinding | Intervention | Control | Follow-up (month) | Lifestyle intervention | Jadad score |
---|---|---|---|---|---|---|
BIP study [8] (2000) | Double | Bezafibrate 400 mg daily | Placebo | 74.4 | Yes | 4 |
VA-HIT study [10] (1999) | Double | Gemfibrozil 1200 mg daily | Placebo | 36–60 | Yes | 4 |
Acheson J [17] (1972) | Open | Clofibrate 1–2 g daily | Corn oil then placebo | 104 in treatment group 91 in placebo group | NR | 0 |
Veterans Administration Cooperative Study Group [18] (1973) | Double | Clofibrate 2 g daily | Placebo | 54 | NR | 1 |
Coronary Drug Project Research Group [19] (1975) | Double | Clofibrate 1.8 g daily | Placebo | 74.4 | NR | 4 |
WHO-COOP committee of principal Investigators [20] (1978) | Double | Clofibrate 1.6 g daily | Olive oil Placebo | 63.6 | Yes | 2 |
Double | Bezafibrate 400 mg daily | Placebo | 55.2 | NR | 2 | |
E J Whitney [23] (2005) | Double | Gemfibrozil 600 mg daily | Placebo | 30 | Yes | 3 |
FIELD study [24] (2005) | Double | Fenofibrate 200 mg daily | Placebo | 60 | Yes | 4 |
The ACCORD Study Group [25] (2010) | Double | Fenofibrate 160 mg daily | Placebo | 56.4 | Yes | 4 |