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Table 2 Design of trials included in the systematic review and meta-analysis

From: Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention

Source

Blinding

Intervention

Control

Follow-up (month)

Lifestyle intervention

Jadad score

BIP study [8] (2000)

Double

Bezafibrate 400 mg daily

Placebo

74.4

Yes

4

VA-HIT study [10] (1999)

Double

Gemfibrozil 1200 mg daily

Placebo

36–60

Yes

4

Acheson J [17] (1972)

Open

Clofibrate 1–2 g daily

Corn oil then placebo

104 in treatment group 91 in placebo group

NR

0

Veterans Administration Cooperative Study Group [18] (1973)

Double

Clofibrate 2 g daily

Placebo

54

NR

1

Coronary Drug Project Research Group [19] (1975)

Double

Clofibrate 1.8 g daily

Placebo

74.4

NR

4

WHO-COOP committee of principal Investigators [20] (1978)

Double

Clofibrate 1.6 g daily

Olive oil Placebo

63.6

Yes

2

LEADER study [21, 22] (2002)

Double

Bezafibrate 400 mg daily

Placebo

55.2

NR

2

E J Whitney [23] (2005)

Double

Gemfibrozil 600 mg daily

Placebo

30

Yes

3

FIELD study [24] (2005)

Double

Fenofibrate 200 mg daily

Placebo

60

Yes

4

The ACCORD Study Group [25] (2010)

Double

Fenofibrate 160 mg daily

Placebo

56.4

Yes

4