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Table 4 Relative risk of stroke and change in total cholesterol and triglyceride concentration between fibrates and placebo therapy

From: Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention

Source

Triglyceride lowering

Total cholesterol lowering

Relative risk (RR) and 95% CI for stroke

Relative risk (RR) and 95% CI for fatal stroke

BIP study [8] (2000)

11.0%

3.0%

0.93 (0.68, 1.27)

-

VA-HIT study [10] (1999)

31.0%

4.0%

0.73 (0.53, 1.00)

0.33 (0.09, 1.23)

Acheson J [17] (1972)

NR

6.4%

1.07 (0.70, 1.63)

0.41 (0.08, 2.00)

Veterans Administration Cooperative Study Group [18] (1973)

33.2%

3.7%

1.58 (0.97, 2.59)

0.70 (0.23, 2.19)

Coronary Drug Project Research Group [19] (1975)

22.3%

6.5%

1.11 (0.92, 1.34)

-

WHO-COOP committee of principal Investigators [20] (1978)

NR

9.0%

1.18 (0.71, 1.96)

0.99 (0.47, 2.08)

LEADER study [21, 22] (2002)

23.4%

8.1%

1.23 (0.85, 1.77)

1.45 (0.62, 3.37)

E J Whitney [23] (2005)

21.5%

6.8%

0.90 (0.73, 1.12)

-

FIELD study [24] (2005)

49.8%

19.6%

0.20 (0.01, 4.15)

-

The ACCORD Study Group [25] (2010)

15.6%

NR

1.06 (0.72, 1.56)

0.50 (0.15, 1.65)